医用回旋加速器的^(64)Cu高效制备  

Medical Cyclotron Production of ^(64)Cu

作　　者：孙夕林[1,2] 闫 王凯[1,2] 林艳红[1,2] 方芳[1,2] 刘芳[1,2] 杨丽丽[1,2] 申宝忠[1,2] 

机构地区：[1]哈尔滨医科大学附属第四医院TOF-PET/CT/MR中心,黑龙江哈尔滨150028 [2]哈尔滨医科大学分子影像研究中心,黑龙江哈尔滨150028

出　　处：《现代生物医学进展》2016年第19期3783-3787,3800,共6页Progress in Modern Biomedicine

基　　金：黑龙江省教育厅科技研究项目(12521184)

摘　　要：铜-64(半衰期12.7小时)是PET上常用的一种正电子放射性核素,其不仅能够作为示踪剂同时还能够用于治疗,特别是对癌症的放射治疗,效果显著。以往^(64)Cu只有通过核研究反应堆快速中子通量捕获才能生产(即质子流轰击锌),反应周期长且成本高,极大的限制了^(64)Cu的生产和应用。为实现^(64)Cu的大量生产、应用同时节约成本,国际上已开展医用回旋加速器^(64)Cu的高效制备研究,目前最常使用的是64Ni经质子束流轰击后发生核反应产生^(64)Cu。通过结合我中心实际操作经验,本文旨在阐述医用回旋加速器(能量16.5Me V)高效制备^(64)Cu的方法。以天然镍粉为电镀原材料。将其电镀成功后,利用30微安的质子束流开始轰靶,最后通过离子交换柱将^(64)Cu、64Ni和其他放射性产物快速分离,从而得到纯度高、放射性活度高的^(64)Cu。Copper-64（T1/2=12.7 h） was a useful radiotracer for positron emission tomography as well as a promising radiotherapy agent in the cancer treatment. Copper-64 has been produced in the fast neutron fluxtrap（irradiation of zinc with fast neutrons）, the reaction cycle was long and very high cost, making the availability of this copper-64 very limited. In order to significantly increase the availability of this intermediate-lived radiotracer, we have investigated and developed a method for the efficient production of high specific activity copper-64 using a small biomedical cyclotron（16.5 Me V）. The most common way of the production of copper-64 was the64^Ni（p, n）64^Cu nuclear reaction. Nickel has been electroplated successfully at weight of about 30 mg and bombarded with proton currents of 30 μA. Separation of the copper-64, Nickel-64 and other radioactive production by using the ion exchange column, we can get high purity and activity of copper-64.

关 键 词：铜-64 镍-64 医用回旋加速器 固体靶 正电子发射计算机断层扫描 

分 类 号：R445[医药卫生—影像医学与核医学] R814.42[医药卫生—诊断学]