中东呼吸综合征冠状病毒重组疫苗研究进展  

Novel Research Progress of the Recombinant Vaccine for MERS-CoV

作　　者：胡慧祯 沈宇清[1] 

机构地区：[1]东南大学医学院,南京210009

出　　处：《病毒学报》2016年第4期495-500,共6页Chinese Journal of Virology

基　　金：东南大学教学改革研究项目资助(No.2015-120)

摘　　要：中东呼吸综合征冠状病毒(Middle East respiratory syndrome corona virus,MERS-CoV)自发现以来就引起了人们的广泛关注,研制针对该病毒的有效疫苗成为近期的研究热点。本文主要介绍该病毒重组疫苗方面的研究新进展,包括动物模型的选择以及重组亚单位疫苗、重组活载体疫苗、假病毒疫苗的构建与优化。在对该病毒重组疫苗的研究新进展做出相关总结的基础上,对进一步验证疫苗安全性和有效性等的发展方向提出展望。Respiratory syndrome coronavirus in the Middle East（MERS-CoV）has caused wide attention since it was discovered,and the design of effective vaccines for MERS-CoV becomes a hot area at present.Therefore,this review is aimed at novel research progress of the recombinant vaccine for MERS-CoV,including selection and improvement of animal model for vaccine test,construction and optimization of recombinant subunit vaccine,attempts at recombinant live vector vaccine based on varies of vectors,as well as the advantages of pseudovirus.In conclusion,we make a summary about the novel research progress of the recombinant vaccine for MERS-CoV and a promising prospect of its development in terms of both safety and effectiveness verification in the future will be demonstrated.

关 键 词：MERS-CoV 转基因动物模型 重组亚单位疫苗 重组活载体疫苗 假病毒 

分 类 号：R373.1[医药卫生—病原生物学]