内皮型一氧化氮合酶活性的调节与心血管疾病的研究进展  

Research progress in the regulation of endothelial nitric oxide synthase activity and cardiovascular diseases

作　　者：刘昭娅 胥茜[1] 唐义信[1] 石瑞正[1] 

机构地区：[1]中南大学湘雅医院心内科,长沙410008

出　　处：《中南大学学报（医学版）》2016年第6期632-636,共5页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(81170261);国家自然科学基金青年基金(81102440);国家重点基础研究发展计划(2014CB542402);中国博士后基金(2013M542143)~~

摘　　要：内皮型一氧化氮合酶(endothelial nitric oxide synthase,e NOS)是合成一氧化氮(nitiric oxide,NO)起主要作用的酶,e NOS和NO在调节血管壁结构和功能中有重要作用,参与心血管疾病的病理生理过程。e NOS活性的改变除了常见的磷酸化途径外,还涉及乙酰化、谷胱甘肽化、蛋白质间的相互作用等机制,笔者将简要阐述e NOS的基本结构和功能、e NOS活性的调节途径及其在心血管疾病中的研究进展。Endothelial nitric oxide synthase （eNOS） is a major enzyme responsible for nitric oxide （NO） production. Both eNOS and NO play an important role in regulating vessel structure and function through participating in the physiological and pathological process. Generally, the phosphorylation of eNOS has been recognized as a common mechanism for regulation of eNOS function. However, recent studies have demonstrated several other new mechanisms, such as acetylation, S-glutathionylation, and protein-protein interaction. This review highlights the basic structure and functions of eNOS as well as the relationship between regulation of eNOS activity and cardiovascular diseases.

关 键 词：内皮型一氧化氮合酶 一氧化氮 乙酰化 谷胱甘肽化 

分 类 号：R54[医药卫生—心血管疾病]