刺槐花总黄酮缓释片的研制  

Preparation of Robiniae Pseudoacaciae Flos Total Flavonoids Sustained- Release Tablets

作　　者：李本俊 刘彦辰[2] 初天舒 翟延君[2] 初正云[2] 

机构地区：[1]辽宁医药职业学院,辽宁沈阳110101 [2]辽宁中医药大学药学院,辽宁大连116600 [3]大连美罗中药厂有限公司,辽宁大连116036

出　　处：《中华中医药学刊》2016年第7期1660-1662,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：辽宁省科技攻关项目(2009209001)

摘　　要：目的:筛选刺槐花总黄酮缓释片的最佳配方,考察其释放度。方法:以刺槐花总黄酮的释放度为考察指标,采用单因素试验法,考察3种规格的羟丙基甲基纤维素(HPMC-K4M,K15M,K100M)和乳糖的用量对刺槐花总黄酮释放度的影响;采用正交设计实验对刺槐花总黄酮缓释片的处方进行优化,确定最佳处方。结果:最佳配方为HPMC-K4M的用量为15%,乳糖用量为15%,聚乙烯吡咯烷酮(PVP)的用量为4%,微晶纤维素的用量为20%。按此配方制成的缓释片2 h平均累积释药量约为30%,6 h平均累积释药量约为65%,12 h平均累积释药量超过90%。结论:按筛选的最佳配方制备的刺槐花总黄酮缓释片有较好的控释行为,基本上可以达到控制药物释放速率的要求。Objective： To screen the best formula of Robiniae Pseudoacaciae Flos Total Flavonoids Sustained- Release Tablets and investigate its release rate. Methods： With the release rate of total flavonoids in Robiniae Pseudoacaciae Flos as the investigation index and by using single factor test method,we studied the impact of the amount of hydroxypropyl methyl cellulose with three sizes（ HPMC- K4 M,K15M,K100M） and lactose on release rate of total flavonoids in Robiniae Pseudoacaciae Flos and determined the best prescription by orthogonal design. Results： Best formula： HPMC- K4 M in an amount of 15%,the amount of lactose 15%,Polyvinylpyrrolidone（ PVP） in an amount of 4%,microcrystalline cellulose in an amount of 20%. The accumulated release amount in 2 h was 30% and in 6 h was 65% and in 12 h was over90%. Conclusion： Robiniae Pseudoacaciae Flos Total Flavonoids Sustained- Release Tablets according to the best recipes have better controlled release behavior,which can basically meet the requirements of sustained- release tablets.

关 键 词：刺槐花 总黄酮 缓释片 释放度 

分 类 号：R283.6[医药卫生—中药学]