甲钴胺注射液、血栓通联合安诺治疗仪治疗糖尿病周围神经病变的临床观察  

Mecobalamin Injection,Xueshuantong Combined with Anodyne Therapeutic Apparatus in Treatment of Diabetic Peripheral Neuropathy

作　　者：周丽华[1] 琚枫 陈清华[1] 王毅[1] 符茂雄 

机构地区：[1]海南省农垦总医院内分泌科,海南海口570311

出　　处：《中华中医药学刊》2016年第7期1697-1699,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：海南省卫生厅项目(琼卫2011-73)

摘　　要：目的:对比甲钴胺注射液、血栓通联合安诺治疗仪治疗糖尿病周围神经病变的临床观察。方法:2014年6月—2015年6月收治的90例糖尿病周围神经病变患者,按照数字表法随机分为试验组和对照组,每组45例。对照组患者进行甲钴胺注射液静脉滴注+安诺治疗仪配合治疗,试验组在对照组基础上联合血栓通配合治疗。对比两组患者治疗总有效率、运动神经传导速度(MNCV)及感觉神经传导速度(SNCV)及不良反应发生率。结果:试验组患者治疗总有效率(97.78%)高于对照组(84.45%),但差异在统计学上无意义(P>0.05);但试验组患者周围神经传导速度(60.27±3.93)m/s、(54.98±5.24)m/s、(55.67±5.14)m/s、(61.73±3.21)m/s明显高于对照组(50.28±4.23)m/s、(44.11±4.19)m/s、(42.57±5.46)m/s、(43.38±6.17)m/s,其差异在统计学上有意义(P<0.05);试验组患者经治疗后的不良反应发生率(6.67%)对照组(8.89%)较相近,其差异在统计学上无意义(P>0.05)。结论:应用甲钴胺注射液、血栓通联合安诺治疗仪对糖尿病周围神经病变患者进行治疗,不良反应发生率无明显差异,其临床总有效率及患者周围神经传导速度均有提高,具有较好的短期临床效果,但远期的临床效果还需要通过长期随访和加大样本量来进一步证实。Objective： To compare the clinical effect of Mecobalamin Injection,Xueshuantong combined with anodyne therapeutic apparatus in the treatment of the patients with diabetic peripheral neuropathy. Methods： Ninety cases of diabetic peripheral neuropathy in our hospital from June 2014 to June 2015 were randomly divided into the experimental group and the control group,45 cases in each group. The patients of the control group were treated with Mecobalamin Injection combined with anodyne therapeutic apparatus and the experimental group based on the control group were given Xueshuantong. The total effective rate,motor nerve conduction velocity（ MNCV） and sensory nerve conduction velocity（ SNCV） and the incidence of adverse reactions were compared between two groups. Results： The experimental group＇s total efficiency rate（ 97. 78%） was close with the control group＇s（ 84. 45%） and the difference was statistical significance（ P〈0. 05） but the experimental group＇s peripheral nerve conduction velocity（ 60. 27 ± 3. 93） m / s,（ 54. 98 ±5. 24） m / s,（ 55. 67 ± 5. 14） m / s and（ 61. 73 ± 3. 21） m / s were significantly higher than the control group＇s（ 50. 28 ±4. 23） m / s,（ 44. 11 ± 4. 19） m / s,（ 42. 57 ± 5. 46） m / s and（ 43. 38 ± 6. 17） m / s and the difference was significant（ P〈0. 05）. The incidence rate of adverse reaction after treatment in the experimental group（ 6. 67%） was similar to that（ 8. 89%） in the control group and the difference was not statistically significant（ P〉0. 05）. Conclusion： The clinical effect of Mecobalamin Injection,Xueshuantong combined with anodyne therapeutic apparatus in the treatment of the patients with diabetic peripheral neuropathy is significant and the incidence rate of adverse reaction has no significant difference. The clinical total efficiency rate and patients＇ peripheral nerve conduction velocity are increased significantly. There is a good short- term clinical effect,but the long- term

关 键 词：甲钴胺 血栓通 安诺治疗仪 糖尿病周围神经病变 

分 类 号：R587.2[医药卫生—内分泌]