5-羟色胺转运体启动子区基因型与学龄双生子儿童心理行为问题的相关性  

Correlation of 5-HTTLPR genetype and behavioral problems in school-age twins

作　　者：白丽丽[1] 恩和巴雅尔[1] 李玉玲[1] 丁一[1] 

机构地区：[1]内蒙古师范大学生命科学与技术学院,呼和浩特010022

出　　处：《中华行为医学与脑科学杂志》2016年第6期487-492,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（30960167,31260265）

摘　　要：目的 探讨5-羟色胺转运体基因启动子区（5-hydroxytryptamine transporter gene linkedpolymorphic region,5-HTTLPR）基因型与学龄双生子儿童心理行为问题发生与否的相关性及其与环境因素的交互作用.方法 使用Achenbach儿童行为量表（child behavior checklist,CBCL）对147对6～12岁学龄双生子心理行为问题进行筛查与测评,采用PCR技术对5-HTTLPR基因进行分型,利用广义估计方程进行5-HTTLPR基因型与学龄双生子儿童心理行为问题的相关性分析.结果 （1）学龄双生子儿童行为问题发生的总检出率为24.15％（男：27.94％,女：20.89％）,各行为因子中思维问题的检出率（15.31％）最高,其他各项行为问题的检出率较低（3.40％～8.16％）,儿童行为问题的发生情况性别差异无统计学意义（P＞0.05）.（2）相关分析发现,5-HTTLPR仅与社会化问题的发生情况相关（P＜0.05）,含S基因的个体更易发生社会化问题.（3） 5-HTTLPR与双生子自身因素及家庭环境因素的交互作用分析发现,5-HTTLPR对焦虑抑郁问题存在主效应,含S基因的个体更易发生焦虑抑郁问题;性别对社会化问题存在主效应,男生更易发生社会化问题;5-HTTLPR与双生子自身因素及家庭环境因素均不存在交互作用.结论 5-HTTLPR与学龄双生子儿童社会化和焦虑抑郁问题的发生可能有一定关联,S基因可能是社会化和焦虑抑郁问题的易感基因.Objective To analyze the correlation between 5-hydroxytryptamine transporter gene linked polymorphic region（5-HTTLPR） and twin children＇s behavioral problems and its interaction with environmental factors.Methods A total of 147 pairs of school-age twins aged 6-12 years were enrolled.The behavioral problems were assessed with the Child Behavior Checklist （CBCL）.The genotype of 5-HTTLPR was detected by the method of PCR.The correlation of 5-HTTLPR and children＇s behavioral problems was performed using generalized estimating equation.Results （1） The overall incidence rate of behavioral problems in school-age twins was 24.15% （27.94% in the boys;20.89% in the girls）,in which the rate of thinking problems （15.31%） was the highest,and the rates of other problems were lower （3.40%-8.16%）.（2） The results of correlation analysis showed that 5-HTTLPR was only related to the social problems （P〈 0.05）.The S allele of 5-HTTLPR maybe associated with the social problems.（3） The results of interaction of 5-HTTLPR with twin factors of themselves and family environmental factors showed that 5-HTTLPR was the main effect of the anxious/depressed problems,and S allele carriers were easier to occur anxious/depressed problems.Gender was the main effect of the social problems,and boys were easier to occur social problems.There was no significant interaction between 5-HTTLPR and twin factors of themselves and family environmental factors.Conclusion 5-HTTLPR genetype may have some relevance to the social and anxious/depressed problems,and S allele may be a susceptibility gene of social and anxious/depressed problems.

关 键 词：5-HTTLPR 学龄双生子 行为问题 

分 类 号：R179[医药卫生—妇幼卫生保健] B844.1[医药卫生—公共卫生与预防医学]