心房颤动患者单个核细胞硫化氢产率的变化  

Hydrogen sulfide productivity of mononuclear cells from patients with atrial fibrillation

作　　者：韩霖[1] 石慧丽[1] 钟光珍[1] 徐琳[1] 

机构地区：[1]首都医科大学附属北京朝阳医院心脏中心,100020

出　　处：《实用医学杂志》2016年第12期1955-1958,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81300148);北京市卫生局高层次人才项目(编号:2011)

摘　　要：目的:研究心房颤动患者单个核细胞硫化氢产率的变化。方法:取60例心房颤动患者(房颤组)、30例健康对照受试者(对照组)空腹血液,分离单个核细胞,用改良亚甲基蓝法测定其硫化氢产率,并与心房颤动特有的相关指标做相关分析。结果:房颤组单个核细胞硫化氢产率比对照组高92.5%[10.63(8.21~14.37)μmol·min^(-1)·g·protein^(-1)vs.5.52(4.42~8.50)μmol·min^(-1)·g·protein^(-1)]。并且硫化氢产率与左房横径显著相关(r=0.276,P<0.01),而硫化氢产率与左室舒张末径、左房长径、C-反应蛋白等无显著相关。结论:心房颤动患者单个核细胞硫化氢产率上调。Objective To study the hydrogen sulfide productivity by mononuclear cells in patients with atrial fibrillation （AF）. Methods Mononuclear cells were extracted from peripherial blood of 60 AF patients and 30 healthy controls. Modified methylene blue method was used to evaluate the hydrogen sulfide productivity of mononuclear cells. Results Hydrogen sulfide productivity of mononuclear cells from AF patients was 92.5%higher than that from control [10.63 （8.21~14.37） μmol/（min.g protein） vs 5.52 （4.42~8.50） μmol/（min.g protein）]. Hydrogen sulfide productivity of mononuclear cells was correlated with the left atrial transverse diameter （r = 0.276,P 〈 0.01）, while no significant correlation was found between hydrogen sulfide and left ventricular end-diastolic diameter , left atrial anterior posterior diameter , C-reaction protein etc. Conclusion Hydrogen sulfide productivity of mononuclear cells from AF patients is promoted.

关 键 词：心房颤动 硫化氢 单个核细胞 

分 类 号：R541.75[医药卫生—心血管疾病]