卵泡刺激素受体基因多态性与卵巢过度刺激综合征的相关性  

Correlation between the follicle-stimulating hormone receptor gene polymorphism and the ovarian hyperstimulation syndrome

作　　者：沈亚[1] 陈丽[1] 谭小方[1] 张晶晶[1] 施蔚虹[1] 

机构地区：[1]江苏省南通市妇幼保健院生殖中心,226000

出　　处：《实用医学杂志》2016年第12期1994-1997,共4页The Journal of Practical Medicine

基　　金：南通市社会事业科技创新与示范项目(编号:HS2014011)

摘　　要：目的:探索卵巢过度刺激综合征(OHSS)与卵泡刺激素受体基因(FSHR)307位点和680位点的相关性。方法:对202例接受IVF-ET治疗的女性不孕症患者的血液样本进行FSHR基因307位点和680位点的分型鉴定。结果:OHSS组患者的680这个位点中基因型频率AA,AG,GG分别为51.1%,38.3%,10.6%,等位基因频率A,G分别为70.2%,29.8%,基因型及等位基因频率分布均与非OHSS组比较差异有统计学意义,在307这个位点上未有类似发现。结论:该研究结果表明FSHR基因的Asn680Ser这个位点可能与OHSS发病相关,Thr307Ala这个位点需要进一步的研究。Objective To investigate the relationship between OHSS and FSHR gene polymorphism. Methods Two hundred and two women were enrolled in this study. The FSHR gene polymorphisms at position 307 and 680 were detected. Results The distribution of the allele frequency and genotype frequency of the position 680 in FSHR gene were significantly different between women with OHSS or not. No significant differences of the position 307 in FSHR gene were observed. Conclusion Themutation of Asn680Ser in FSHR might be closely related with OHSS.

关 键 词：卵泡刺激素受体 卵巢过度刺激综合征 单核苷酸基因多态性 

分 类 号：R714.8[医药卫生—妇产科学]