老年人群梅毒抗体酶联免疫吸附试验检测假阳性结果原因分析  

Analysis of false positive results by TP-ELISA analysis in elderly

作　　者：杨洪鹏[1] 赵利[1] 刘琳[1] 

机构地区：[1]徐州市肿瘤医院检验科,江苏省徐州221005

出　　处：《中国基层医药》2016年第14期2220-2222,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨老年人群梅毒检测高假阳性结果的的原因。方法选取1200例检测者血清，将其分为老年组（≥60岁）和对照组（＜60岁），采用快速血浆反应素卡片试验（RPR）、酶联免疫吸附试验（TP-ELISA）及梅毒螺旋体明胶凝集试验（TPPA）检测受检人群梅毒螺旋体抗体，以 TPPA 作为确证实验，统计TP-ELISA 法的假阳性率，并对结果进行分析。结果老年组 TP-ELISA 检测阳性率（8．00％）及假阳性率（4.50％）高于对照组阳性率（3．83％）及假阳性率（1．87％），差异有统计学意义（χ2＝9．36、9．47，均 P ＜0.05）；并且老年组假阳性率随着年龄的增长而呈现明显升高的趋势。结论老年患者梅毒检测易产生假阳性，原因可能与患者本身身体状况有关，应结合临床表现进行诊断。Objective To investigate the causes of high rate of false positives in the detection of syphilis in elderly patients.Methods We used RPR,TP -ELISA and TPPA to detect the antibody of syphilis in 1 200 patients, and the samples were divided into the elderly group （60 or higher）and the control group （〈60 years old）,confirmed by TPPA,then counted the positive rate and false positive rate,and the results were analyzed.Results The positive rate （8.00%）and false positive rate （4.50%）of the elderly group were significantly higher than the control group （3.83%,1.87%,χ2 =9.36,9.47,all P 〈0.05）.The false positive rate significantly rised with the increase of age of the elderly group.Conclusion The reason of false positive may be associated with the physical condition of the patients,and we should consider it with the clinical manifestations when diagnosed.

关 键 词：梅毒 老年人群 假阳性 

分 类 号：R759.1[医药卫生—皮肤病学与性病学] R446.6[医药卫生—临床医学]