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作 者:Pogula Sreekanth Reddy Motakatla Venkata Krishna Reddy Peddiahgari Vasu Govardhana Reddy
机构地区:[1]Department of Chemistry, Yogi Vemana University
出 处:《Chinese Chemical Letters》2016年第6期943-947,共5页中国化学快报(英文版)
基 金:supported by the Department of Science and Technology (DST);New Delhi, India (No. SR/FT/CS-013/2010)
摘 要:A series of camphor-derived thiourea organocatalysts 3a–f were designed and synthesized from(1R,3S)-camphoric acid 1 and applied to the one-pot three-component Kabachnik–Fields reaction. Catalyst 3c was found to be an efficient organocatalyst for the reaction of 2-cyclopropylpyrimidin-4-carbaldehyde 4,various amines 5, and diphenylphosphite 6 to yield the corresponding enantioselective a-aminophosphonates 7a–e in 74%–82% yields and 14%–35% ee.A series of camphor-derived thiourea organocatalysts 3a–f were designed and synthesized from(1R,3S)-camphoric acid 1 and applied to the one-pot three-component Kabachnik–Fields reaction. Catalyst 3c was found to be an efficient organocatalyst for the reaction of 2-cyclopropylpyrimidin-4-carbaldehyde 4,various amines 5, and diphenylphosphite 6 to yield the corresponding enantioselective a-aminophosphonates 7a–e in 74%–82% yields and 14%–35% ee.
关 键 词:Asymmetric organocatalysis (1R 3S)-Camphoric acid Camphor-derived thioureas Chiral a-aminophosphonates Enantioselective Kabachnik-Fields reaction
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