Camphor-derived thioureas: Synthesis and application in asymmetric Kabachnik-Fields reaction  

Camphor-derived thioureas: Synthesis and application in asymmetric Kabachnik-Fields reaction

在线阅读下载全文

作  者:Pogula Sreekanth Reddy Motakatla Venkata Krishna Reddy Peddiahgari Vasu Govardhana Reddy 

机构地区:[1]Department of Chemistry, Yogi Vemana University

出  处:《Chinese Chemical Letters》2016年第6期943-947,共5页中国化学快报(英文版)

基  金:supported by the Department of Science and Technology (DST);New Delhi, India (No. SR/FT/CS-013/2010)

摘  要:A series of camphor-derived thiourea organocatalysts 3a–f were designed and synthesized from(1R,3S)-camphoric acid 1 and applied to the one-pot three-component Kabachnik–Fields reaction. Catalyst 3c was found to be an efficient organocatalyst for the reaction of 2-cyclopropylpyrimidin-4-carbaldehyde 4,various amines 5, and diphenylphosphite 6 to yield the corresponding enantioselective a-aminophosphonates 7a–e in 74%–82% yields and 14%–35% ee.A series of camphor-derived thiourea organocatalysts 3a–f were designed and synthesized from(1R,3S)-camphoric acid 1 and applied to the one-pot three-component Kabachnik–Fields reaction. Catalyst 3c was found to be an efficient organocatalyst for the reaction of 2-cyclopropylpyrimidin-4-carbaldehyde 4,various amines 5, and diphenylphosphite 6 to yield the corresponding enantioselective a-aminophosphonates 7a–e in 74%–82% yields and 14%–35% ee.

关 键 词:Asymmetric organocatalysis (1R 3S)-Camphoric acid Camphor-derived thioureas Chiral a-aminophosphonates Enantioselective Kabachnik-Fields reaction 

分 类 号:O621.251[理学—有机化学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象