Palcernuine, the first [5/6/6/6]-cernuane-type alkaloid from Palhinhaea cernua f.sikkimensis  

作　　者：Yu Tang Juan Xiong Yike Zou Bastien Nay Li-Jun Wang Jin-Feng Hu 

机构地区：[1]Department of Natural Products Chemistry,School of Pharmacy,Fudan University,Shanghai 201203,China [2]Department of Chemistry,University of Pennsylvania,Philadelphia 19104-6323,USA [3]Unite Molecules de Communication et Adaptation des Micro-organismes,Sorbonne Universites,Museum National d'Histoire Naturelle,Centre National de la Recherche Scientifique(CNRS UMR 7245),Paris 75005,France

出　　处：《Chinese Chemical Letters》2016年第6期969-973,共5页中国化学快报（英文版）

基　　金：supported by NSFC grants (Nos. 21472021, 81273401, 81202420);grants from the Ph.D. Programs Foundation of Ministry of Education (MOE) of China (Nos. 20120071110049, 20120071120049);the National Basic Research Program of China (973 Program, No. 2013CB530700)

摘　　要：One novel（named palcernuine, 1） and five known cernuane-type（2–6） alkaloids were isolated from the whole plant of Palhinhaea cernua f. sikkimensis. The structure of 1, possessing an unprecedented [5/6/6/6]-tetracyclic ring system containing two nitrogen atoms, was established on the basis of spectroscopic methods, and its absolute configuration was determined by comparison of the experimental and calculated electronic circular dichroism（ECD） spectra. A plausible biosynthetic pathway to 1 is proposed.One novel（named palcernuine, 1） and five known cernuane-type（2–6） alkaloids were isolated from the whole plant of Palhinhaea cernua f. sikkimensis. The structure of 1, possessing an unprecedented [5/6/6/6]-tetracyclic ring system containing two nitrogen atoms, was established on the basis of spectroscopic methods, and its absolute configuration was determined by comparison of the experimental and calculated electronic circular dichroism（ECD） spectra. A plausible biosynthetic pathway to 1 is proposed.

关 键 词：Palhinhaea cernua f.sikkimensis LYCOPODIACEAE Palcernuine Cernuane-type alkaloids Biosynthetic pathway 

分 类 号：O629.3[理学—有机化学] TQ153.12[理学—化学]