紫心甘薯黄酮不同极性提取液对IR-HepG2细胞的作用  

Effects of Purple Sweet Potato Flavonoids in Extracts with Different Polarity on IR-Hep G2 Cells

作　　者：南李 李亚芳[2] 张翀[3] 申屠景超 

机构地区：[1]杭州市妇产科医院药剂科,杭州310008 [2]杭州市第一人民医院药剂科 [3]浙江大学城市学院医学院

出　　处：《中国药师》2016年第7期1239-1241,共3页China Pharmacist

基　　金：浙江省中医药科学研究基金(编号:2013ZA102)

摘　　要：目的:初步探讨紫心甘薯黄酮(PSPF)不同极性提取液对胰岛素抵抗Hep G2细胞(IR-Hep G2)的作用。方法:采用PSPF的不同极性提取液干预IR-Hep G2模型,观察加样后IR-Hep G2细胞与未加样组的剩余葡萄糖量。结果:PSPF、PSPF氯仿提取液的高、中、低剂量组及PSPF正丁醇提取液的高、中剂量组葡萄糖剩余浓度小于IR-Hep G2组(P<0.05),结果有统计学意义。结论:PSPF、PSPF的氯仿提取液及正丁醇提取液均具有增强IR-Hep G2细胞葡萄糖消耗能力的作用。Objective：To investigate the effects of purple sweet potato flavonoids （PSPF）in the extracts with different polarity on the insulin resistant HepG2 （IR-HepG2） cells.Methods： PSPF in the extracts with different polarity was used to intervene the IR-HepG2 model, and the remaining glucose concentration in the IR-HepG2 group and PSPF intervention groups was compared .Results：The remaining glucose concentration in PSPF intervention group , PSPF with chloroform as the extracting solvent at high , medium and low dose of PSPF , and PSPF with butanol as the extracting solvent at high and medium dose of PSPF was obviously lower than that in the IR-HepG2 group（P〈0.05）.Conclusion：PSPF, the chloroform extract of PSPF and the butanol extract of PSPF can enhance the consumption of glucose in IR-HepG2 cells.

关 键 词：紫心甘薯黄酮 胰岛素抵抗 HEP G2细胞 

分 类 号：R285.5[医药卫生—中药学]