蒲公英抗肿瘤活性的研究进展  

Research Progress in Antitumor Activity of Dandelion

作　　者：熊富良[1] 吴珊珊[1] 李心愿[1] 张雪琼[1] 

机构地区：[1]武汉理工大学化学化工与生命科学学院,武汉430070

出　　处：《中国药师》2016年第7期1363-1366,共4页China Pharmacist

基　　金：重点实验室开放课题基金项目(编号:HLPAI2014005)

摘　　要：目的:综述近五年来蒲公英抗肿瘤活性的研究进展。方法:搜集近五年来蒲公英不同提取物抗肿瘤方面的研究文献,从蒲公英中有效成分多糖,三萜类,植物甾醇类,黄酮类,有机酸类等方面阐述其抗肿瘤活性。结果:蒲公英具有抗肿瘤作用。蒲公英有效成分多糖可以有效的阻止胰腺癌PANC-1细胞增殖,羽扇豆醇能削弱人乳腺癌MCF-7细胞的活性,β-谷甾醇能诱导人宫颈癌Hela细胞凋亡等。结论:蒲公英可以有效的治疗胰腺癌,乳腺癌,宫颈癌等。蒲公英其他有效成分是否具有抗肿瘤作用需要进一步研究,为其成为潜在的临床抗肿瘤中药提供完备的依据。Objective：To summarize the research advance in antitumor activity of dandelion in recent 5 years.Methods：The lit-eratures on the antitumor activity of various extracts of dandelion in recent 5 years were collected , including the effective components such as polysaccharide , triterpenes , phytosterols , flavonoids and organic acids etc .Results：Dandelion showed antitumor activity .The polysaccharide ingredients could effectively prevent the proliferation of pancreatic cancer PANC -1 cells, lupeol could reduce the activity of breast cancer MCF-7 cells, and beta sitosterol could induce the apoptosis of human cervical cancer Hela cells .Conclusion：Dande-lion is effective in the treatment of pancreatic cancer , breast cancer and cervical cance etc .The antitumor activity of the other active in-gredients in dandelion needs further research in order to provide complete theoretical and experimental evidence for the potential appli -cation as antitumor medicine in clinics .

关 键 词：蒲公英 提取物 抗肿瘤 进展 

分 类 号：R282.71[医药卫生—中药学]