消白胶囊的小鼠急性毒性研究  

Study on Acute Toxicity of Xiaobai Capsules in Mice

作　　者：宋洋洋[1] 兰婷[2] 李明华[2] 李晓晔[1] 张衍国[3] 李穆琼[1] 

机构地区：[1]第四军医大学药学系药物化学教研室,西安710032 [2]第四军医大学药学系化学教研室 [3]唐都医院皮肤科

出　　处：《中国药师》2016年第7期1411-1412,共2页China Pharmacist

基　　金：陕西省自然科学基础研究计划项目(编号:2014JM2-8192)

摘　　要：目的:观察消白胶囊灌胃给药后小鼠的急性毒性反应。方法:小鼠随机分为2组,给药组和空白对照组,给药组灌胃给药,3次/d,观察并记录小鼠口服消白胶囊的急性毒性反应,并计算半数致死量和最大给药量。结果:消白胶囊每日的最大给药剂量为141.6 g·kg-1(相当于临床拟用量的211.3倍),该剂量下小鼠未见明显毒性反应,14 d内动物无1例死亡,解剖后未见对脏器的毒性改变。结论:消白胶囊灌胃给药对小鼠急性毒性甚低,表明该药安全可靠。Objective： To study the acute toxicity of Xiaobai capsules in mice after intragastric administration .Methods： The mice were randomly divided into two groups , the treatment group and the control group .The treatment group was given Xiaobai cap-sules by gavage, 3 times daily.The acute toxicity was recorded, and the median lethal dose （LD50） and the maximum dose were deter-mined.Results：The maximum daily dose of Xiaobai capsules was 141.6 g· kg-1（equivalent to 211.3 times of the clinical dose）.At the dose, the mice showed no toxicity without death in 14 days or changes in organs after the dissection .Conclusion：Xiaobai capsules have very low acute toxicity in mice after intragastric administration with high security .

关 键 词：消白胶囊 急性毒性 半数致死量 最大给药量 

分 类 号：R965.3[医药卫生—药理学]