太赫兹技术用于关节软骨检测的研究进展  

Current Status and Recent Advances in Research and Application of THz Technology in Articular Cartilage Detection

作　　者：马宇婷[1,2] 张瑾[1] 施长城[2] 李薇[2] 韩晓惠[1] 彭晓昱[2] 魏东山[2] 杜春雷[2] 崔洪亮[1,2] 

机构地区：[1]吉林大学仪器科学与电气工程学院,吉林长春130061 [2]中国科学院重庆绿色智能技术研究院,太赫兹技术研究中心,跨尺度制造技术重庆市重点实验室,重庆400714

出　　处：《光谱学与光谱分析》2016年第7期2031-2035,共5页Spectroscopy and Spectral Analysis

基　　金：重庆市基础与前沿研究计划一般项目(cstc2014jcyjA10002);重庆市基础与前沿研究计划重大项目(cstc2013jcyjC00001);重庆市应用开发重大项目(cstc2013yykfC00007);十二五”国家科技支撑计划项目(2012BAK04B03)资助

摘　　要：骨关节炎是主要由软骨组织损伤与退化引起的常见关节疾病,是影响人类健康的重大疾病之一,对于关节软骨组织早期病变的检测可以大大提高疾病的治愈率,然而相关的临床诊断技术尚未发现。近年来,太赫兹技术在医学领域日益受到关注。与传统方法相比,太赫兹辐射能量低,不会产生电离辐射,可高灵敏、无损伤地对生物组织进行成像检测,因此在关节软骨诊断方面具有较大的应用潜力。本文简要介绍了关节软骨的生理与病理情况以及目前关节软骨检测的主要方法,重点总结了太赫兹技术应用于关节软骨检测方面的相关研究工作,分别包括对动物与人类关节软骨的检测,探讨了太赫兹技术在关节软骨检测中所面临的挑战与未来研究展望。Osteoarthritis is a common arthritis disease caused by cartilage tissue damage and degeneration ,which is one of the large epidemics that affect human health .The early detection of the pathological changes of articular cartilage can greatly im-prove the cure rate of disease ,but the relevant clinical diagnosis technology has not been developed .In recent years ,the applica-tions and researches of terahertz technology are increasingly valued and it has drawn great attention in the field of medicine . Compared with traditional methods ,the terahertz radiation is low-energy and non-ionizing whose spectral-fingerprinting capabili-ty is well-known in the biological world .Meanwhile ,THz technology has a great potential in diagnosis of articular cartilage early degeneration .This paper briefly introduces the physiological and pathological conditions of the articular cartilage ,the current clinical techniques of articular cartilage detection .It mainly summarizes the terahertz technology used for detecting articular carti-lage ,including detection of animal and human cartilage respectively .At last ,the challenges and development prospects of tera-hertz technology in articular cartilage detection are discussed .

关 键 词：关节软骨 太赫兹光谱分析 太赫兹成像 医学诊断 

分 类 号：R318.5[医药卫生—生物医学工程] TN219[医药卫生—基础医学]