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作 者:孙虹[1] 张玉华[1] 徐伟明[1] 崔明玉[1] 娜琴[1] 王静媛[1] 陈阿梅[1]
出 处:《中国优生与遗传杂志》2016年第7期20-21,共2页Chinese Journal of Birth Health & Heredity
基 金:内蒙古自然科学基金资助项目(2013MS1191)
摘 要:目的调查内蒙地区汉族椎间盘退变人群的ACE基因I/N的多态性,并同汉族健康人群比较,分析其遗传特点。方法应用ACE基因内含子16多态部位侧翼的前体进行PCR扩增。等位基因在琼脂胶上电泳,溴乙啶染色,紫外灯下观察。结果椎间盘退变人群的DD,DI和II基因型的频率是0.12,0.63和0.24、健康人群的DD,DI和II基因型的频率是0.33,0.32和0.35。结论在内蒙古地区汉族人群的研究中发现ACE基因I/N的多态性与椎间盘退变相关。Objective:To investigate the Insertion/Deletion(I/N)Polymorphism of angiotensin converting enzyme(ACE)in the patient with disc degeneration in inner Mongolia,and analysis their genetics characteristics. Methods:Genomic DNA was amplified by polymorphic region in intron 16 of the ACE gene. Allele were detected on agarose gel stained with ethidium bromide. Results:The frequencies of DD,DI and II genotype were 0.12,0.63 and 0.24 in disc degeneration and 0.33,0,32 and 0.35 in the control;respectively. Conclusion:Our study demonstrated that For in intron 16 of the ACE gene polymorphisms,DD,DIgenotype,allele I were found to be significantly associated with disc degeneration risk in Inner Mongolia in Chinese population.
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