新型烟酰胺类杀菌剂啶酰菌胺的合成  

Synthesis of the Novel Nicotinamide Fungicide Boscalid

作　　者：张慧丽 张文 康永利 姚晓龙 王轩 栗晓东 

机构地区：[1]天津市均凯化工科技有限公司,天津300384

出　　处：《农药》2016年第7期491-492,503,共3页Agrochemicals

基　　金：天津市科技支撑计划重点项目(15ZCZDNC00100)

摘　　要：[方法]以2-氯硝基苯和2-氯烟酸为主要起始原料,分别经锌粉还原和氯化亚砜氯代,再进行酰化反应生成2-氯-N-(2-氯苯基)吡啶-3-甲酰胺,最后与4-氯苯硼酸进行偶联反应生成啶酰菌胺。[结果]啶酰菌胺的总收率为67%。[结论]该路线具有成本低、收率高、原材料易得、环境友好等优点。[Methods] The synthesis method of fungicide boscalid： 2-nitrochlorobenzene and 2-chloronicotinic acid as main starting materials, were respectively reduced by zinc powder and acylated by sulfoxide, followed by acylation to get 2-chloro-N-（2-chlorophenyl）nicotinamide, finally reacted with 4-chlorophenylboronic acid to achieve boscalid. [Results] The total yield of boscalid was 67%. [Conclusions] This route has some advantages of low cost, high yield, commercially available raw materials, environment friendly, etc.

关 键 词：啶酰菌胺 2-氯烟酰氯 对氯苯硼酸 邻氯苯胺 

分 类 号：TQ455.4[化学工程—农药化工]