血清IFN-γ、IL-4、IL-5及IL-17对儿童哮喘影响及相关性研究  

Effect and correlation on serum IFN-γ,IL-4,IL-5 and IL-17 on children with asthma

作　　者：朱勇斌[1] 蔡幸生[1] 徐海玲[1] 

机构地区：[1]揭阳市人民医院儿科,广东揭阳522091

出　　处：《临床肺科杂志》2016年第8期1401-1403,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的：探究血清 IFN-γ、IL-4、IL-5及 IL-17对儿童哮喘影响及相关性。方法分析2013年1月～2014年6月在我院收治的39例哮喘急性期儿童的临床资料，并列为观察组，选取37例在我院进行健康检查的健康儿童作为对照组。结果观察组患者血清 IFN-γ、IL-4、IL-5及 IL-17水平显著高于对照组，差异具有统计学意义（P ＜0.05）；观察组患者 VC％、FEV1／FVC％、MMER 水平明显低于对照组，差异具有统计学意义（P ＜0.05）；观察组患者 IFN-γ、IL-4、IL-5、IL-17水平与 FEV1／FVC（％）水平呈现显著负相关。结论儿童哮喘发病与 Th1、Th2及 Th17细胞分泌的 IFN-γ、IL-4、IL-5及 IL-17有关，其表达水平升高与哮喘的严重程度呈正比。Objective To investigate the effect and correlation on serum IFN-γ,IL-4,IL-5 and IL-17 on children with asthma.Methods The clinical data of 39 children with asthma in our hospital from January 2013 to June 2014 were analyzed as the observation group,and another 37 healthy children in our hospital were taken as the control group.Results The levels of serum IFN-γ,IL-4,IL-5 and IL-17 were significantly higher in the observation group than in the control group （P〈0.05）.The value of VC%,FEV1/FVC%and MMER was significantly lower in the observation group than in the control group （P〈0.05）.Interferon-γ,IL-4,IL-5 and IL-17 were negatively cor- Objective To investigate the effect and correlation on serum IFN-γ,IL-4,IL-5 and IL-17 on children with asthma.Methods The clinical data of 39 children with asthma in our hospital from January 2013 to June 2014 were analyzed as the observation group,and another 37 healthy children in our hospital were taken as the control group.Results The levels of serum IFN-γ,IL-4,IL-5 and IL-17 were significantly higher in the observation group than in the control group （P 〈0.05）.The value of VC%,FEV1 /FVC% and MMER was significantly lower in the observation group than in the control group （P 〈0.05）.Interferon-γ,IL-4,IL-5 and IL-17 were negatively cor-related with FEV1 /FVC （%）in the observation group.Conclusion The onset of childhood asthma is correlated with IFN-γ,IL-4,IL-5 and IL-17 which are secreted from Th1,Th2 and Th17 cells,and the high expression is posi-tively correlated with its severity. related with FEV1/FVC （%）in the observation group.Conclusion The onset of childhood asthma is correlated with IFN-γ,IL-4,IL-5 and IL-17 which are secreted from Th1,Th2 and Th17 cells,and the high expression is posi-tively correlated with its severity.

关 键 词：哮喘 干扰素-Γ 白细胞介素-4 白细胞介素-5 白细胞介素-17 

分 类 号：R725.6[医药卫生—儿科]