淫羊藿苷对颅脑损伤大鼠血清MBP、GFAP表达的影响  

The effects of Icariin on serum MBP and GFAP levels in traumatic brain injury rats

作　　者：方永军[1] 周雄波[1] 周锋[1] 徐泽彪[1] 胡珍渊[1] 范小璇[1] 韦鹏方 

机构地区：[1]陕西中医药大学附属医院,咸阳712000 [2]陕西中医药大学,咸阳712000

出　　处：《陕西中医》2016年第7期923-925,共3页Shaanxi Journal of Traditional Chinese Medicine

基　　金：陕西省咸阳市科技计划项目(2012K16-01;2011K13-01)

摘　　要：目的:探讨不同剂量淫羊藿苷对颅脑损伤大鼠血清MBP、GFAP含量的影响。方法:100只SD大鼠随机分为假手术组、模型组、ICA低剂量治疗组(30mg/kg·d)、中剂量治疗组(60mg/kg·d)及高剂量治疗组(120mg/kg·d)。各组分别在造模后第1、3、7、14天取血,测定血清MBP、GFAP含量。结果:模型组与假手术组同期比较,MBP及GFAP含量增高,差异有统计学意义(P<0.05);各治疗组与模型组同期比较,MBP及GFAP含量降低,差异有统计学意义(P<0.05);高剂量治疗组与低剂量治疗组同期比较,MBP及GFAP含量降低,差异有统计学意义(P<0.05)。结论:Ica对创伤性脑损伤大鼠有脑保护作用,其作用与Ica剂量呈正相关,其机制与抑制MBP、GFAP表达有关。Objective：To investigate the effects of different doses of icariin（ICA）for traumatic brain injury（TBI）in rats serum myelin basic protein（MBP）and glial fibillary acidic protein（GFAP）.Methods：100SD rats were randomly divided into control group,model group,the ICA low dose treatment group（30mg/kg·d）,middle dose treatment group（60mg/kg·d）and high dose treatment group（120mg/kg·d）.The contents of serum MBP and GFAP were determined on day 1,3,7and 14 after operation.Results：The results of model group compared with control over the same period,higher content of MBP and GFAP,the difference was statistically significant（P〈 0.05）;Each treatment group compared with model group at the same time,content of MBP and GFAP is reduced,the difference was statistically significant（P〈0.05）;High dose treatment group compared with the same period lower dose treatment groups,MBP and GFAP content is reduced,the difference was statistically significant（P〈 0.05）.Conclusions ：The ICA in traumatic brain injury in rats with cerebral protection,its effect is positively related with the ICA dose,its mechanism is related to the inhibition of MBP,GFAP expression.

关 键 词：颅脑损伤 动物实验 大鼠 

分 类 号：R651.15[医药卫生—外科学]