红细胞分布宽度与ACS病变严重程度的相关性  

The correlation between red cell distribution width and syndrome severity of acute coronary syndrome

作　　者：新怡康[1] 

机构地区：[1]惠州市第一人民医院,广东惠州516003

出　　处：《热带医学杂志》2016年第6期773-775,共3页Journal of Tropical Medicine

基　　金：惠州市科技计划(医疗卫生)项目(2012Y040)

摘　　要：目的分析红细胞分布宽度(RDW)与急性冠脉综合征(ACS)冠脉病变严重程度及远期预后的相关性。方法选取2013年1月至2014年12月于惠州市第一人民医院接受住院治疗的206例急性冠脉综合征患者作为研究对象,根据患者的冠脉造影结果及是否存在心肌酶学变化分为ACS组(n=130)以及对照组(n=76),对比两组各生化指标、远期心血管不良事件发生情况、并对相关因素行Logistic回归分析。结果 ACS组患者在肌钙蛋白(c Tn I)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、心脏左室射血分数(LVEF)、左心房内径(LVED)等生化指标上均与对照组相差较大,且差异均有统计学意义(P<0.05)。ACS组RDW、NT-Pro BNP高于对照组,差异均有统计学意义[(12.98±0.54)%vs.(12.26±0.41)%,(490.21±100.48)ng/ml vs.(49.08±10.46)ng/ml,P<0.05)];ACS组心力衰竭的发生率远高于对照组(7.69%vs.1.32%),且心血管不良事件的总发生率也显著大于对照组(13.85%vs.2.63%),差异均有统计学意义(P<0.05)。经Logistic回归分析,NT-Pro BNP、LDL-C、Apo B以及RDW均是急性冠脉综合征病重的独立危险因素。结论红细胞分布宽度与急性冠脉综合征冠脉病变严重程度呈正相关性。Objective To analyze the correlation between red cell distribution width（RDW） and of acute coronary syndrome（ACS） severity of coronary artery disease and long term prognosis. Methods From January 2013 to December 2014,two years of hospital inpatient acute coronary syndrome patients were analyzed retrospectively. 206 cases of patients with acute coronary treatment, according to the results of coronary angiography in all patients and whether the patients had changes of cardiac enzymes were divided into ACS group（n =130） and control group（n =76）. The biochemical indexes of two groups, long-term cardiovascular adverse events, and the related factors were compared by Logistic regression analysis. Results The levels LVED, LEVF, TC, HDL-C, LDL-C, Apo A1, Apo B, FBG, RDW and NT-Pro BNP, and other biochemical indicators of patients in the ACS group were significantly different from the control group（P〈0.05）.RDW and NT-Pro BNP of ACS group were significantly higher than those of the control group [（12.98 ±0.54）% vs.（12.26 ±0.41）%,（490.21 ±100.48） ng / ml vs.（49.08 ±10.46）ng / ml, P〈0.05） ]. The incidence of heart failure and cardiovascular adverse events（7.69% vs. 1.32%）in ACS group was higher than the control group. The total incidence rate of the ACS group was significantly higher than that of the control group（13.85% vs. 2.63%）（P〈0.05）.The Logistic regression analysis indicated that NT-Pro BNP, LDL-C, Apo B and RDW were independent risk factors of acute coronary syndrome in critically ill. Conclusion The red cell distribution width in patients with acute coronary syndrome and the severity of coronary artery disease was positively correlated, but negatively correlated with prognosis.

关 键 词：红细胞分布宽度 急性冠脉综合征 冠脉病变 相关性 

分 类 号：R541.14[医药卫生—心血管疾病]