金花茶提取物体内外抗肿瘤作用研究  

Anti-tumor Effects of Camellia chrysantha(Hu)Tuyama Extracts in Vivo and in Vitro

作　　者：黄悦[1] 侯晓莹[1] 郭恒[1] 林森森[1] 袁胜涛[1] 孙立[1] 

机构地区：[1]中国药科大学江苏省新药筛选中心,江苏南京210009

出　　处：《亚太传统医药》2016年第14期8-11,共4页Asia-Pacific Traditional Medicine

基　　金：国家高技术研究发展计划(863计划)(2014AA022208)

摘　　要：目的:观察金花茶提取物的体内外抗肿瘤作用。方法:采用MTT法检测4种金花茶提取物对3种人胃癌细胞(MGC-803、HGC-27、SGC-7901)及人乳腺癌细胞MDA-MB-435的抑制作用;采用小鼠肉瘤S180模型观察其体内抗肿瘤作用。结果:在体外实验中,金花茶提取物对人胃癌细胞(MGC-803、HGC-27、SGC-7901)和人乳腺癌细胞MDA-MB-435均有显著的抑制作用,并且呈浓度依赖关系;在体内实验中,当剂量为50mg/kg时,JHC-1、2对小鼠肉瘤S180有显著的抑制作用,抑制率分别达42.39%和30.28%。结论:金花茶提取物在体内外均有显著的抗肿瘤作用。Objective：To observe the anti-tumor effects of Camellia chrysantha（Hu） Tuyama extracts in vitro and in vivo. Methods：MTT assay was performed to evaluate the growth inhibitory rate of MGC-803,HGC-27,SGC-7901and MDA-MB-435 ; the S180 xenograft tumor model was established to observe the anti-tumor effects of J HC in vivo. Results：In vitro,Camellia chrysantha Tuyama extract showed significantly inhibition effects on the proliferation of MGC-803, HGC-27,SGC-7901 and MDA-MB-435 in a doseeffect relationship; in vivo,JHC-1,2 showed significantly inhibition effects on $180 （42.39 % and 30.28 %） at the dose of 50mg/kg. Conclusion ： Camellia chrysantha Tuyama has significantly anti-tumor effects in vitro and in vivo.

关 键 词：金花茶 胃癌 肉瘤 抗肿瘤 

分 类 号：R285.5[医药卫生—中药学]