化痰活血方对实验性高脂血症大鼠的研究  

Research of Huatan Huoxue formula on experimental hyperlipidemia rats

作　　者：朱志刚[1] 姚映芷[1] 

机构地区：[1]南京中医药大学基础医学院中药学教研室,硕士研究生210023

出　　处：《环球中医药》2016年第7期785-789,共5页Global Traditional Chinese Medicine

基　　金：南京中医药大学与德国埃尔朗根大学医学院合作项目(015009022001)

摘　　要：目的研究化痰活血方对实验性高脂血症大鼠的影响。方法通过建立高脂血症大鼠模型,灌胃给予化痰活血方(荷叶、海藻、决明子、三七、丹参、姜黄)2659.5 mg/(kg·d),给药4周,测定血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、谷草转氨酶(aspartate transaminase,AST)、谷丙转氨酶(alanine aminotransferase,ALT)、C-反应蛋白(C-reactive protein,CRP),计算动脉粥样硬化指数(AI)和TC/HDL-C,并做肝组织病理切片。结果化痰活血方能降低血清TC、TG、LDL-C的含量及CRP、AI指数、TC/HDL-C比值、AST、ALT。结论化痰活血方对高脂血症大鼠血脂水平具有一定的调节作用,对高脂血症引起的肝功能损伤具有改善作用,且较阿托伐他汀不会引起肝功能损害。Objective To research the effects of Huatan Huoxue formula on experimental hyperlipidemia rats. Methods Hyperlipidemia rats model was established and the Huatan Huoxue formula group was given the administration dosage of 2659. 5 mg /（ kg·d） by gavage for 4 weeks. The serum contents of TC,TG,HDL-C,LDL-C,AST,ALT,CRP were detected and the AI and TC / HDL-C content was figured out. Liver tissue pathological slices was observed. Results Huatan Huoxue formula could effectively reduce the contents of TC,TG,LDL-C,AI,AST,ALT figures,CRP and TC / HDL-C percent. Conclusions Huatan Huoxue formula has a certain regulating effect on blood lipid level in hyperlipidemia rats,and can improve the liver function injury induced by hyperlipidemia,and does not cause liver function damage.

关 键 词：化痰活血方 高脂血症 大鼠实验 

分 类 号：R285.5[医药卫生—中药学]