近十年中药药代动力学新技术新方法概述  

Review on new technologies and methods of pharmacokinetics of traditional Chinese medicines in recent 10 years

作　　者：柏冬[1] 王瑞海[1] 刘丽梅[1] 

机构地区：[1]中国中医科学院中医基础理论研究所,北京100700

出　　处：《环球中医药》2016年第7期891-895,共5页Global Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)(2012CB518401)

摘　　要：中药具有多成分、药效物质不确切的特征,长期以来中药药代动力学的研究存在许多困难。新的仪器、分析技术的出现,提高了中药体内成分分析的灵敏度,使得中药多成分药代研究成为可能。目前认为,在中药药代动力学研究中同时监测多个成分的药代动力学特征是十分有必要的,"中药多组分整合药代动力学研究""中药药代标记物""代谢组学"的研究思路较好地解决了这个问题。但目前的研究仍然存在许多争议,本文对近十年中药药代动力学的新技术与新方法进行综述,希望对中药药代动力学研究提供借鉴。As the chemical compositions in traditional Chinese medicine is very complex and the effective components are not accurate,there are many difficulties in the study of traditional Chinese medicine. With the developments of new technologies and methods,a lot of achievements in the pharmacokinet-ics have been made at home. For example,the emergence of new instruments and analysis technology can improve the sensitivity of the analysis the composition of traditional Chinese medicine in vivo,and make it possible to study the composition of traditional Chinese medicine. It has been reached an agreement that monitoring multi-components＇ pharmacokinetics characteristic at the same time is very necessary. The research idea of＂integral pharmacokinetic study of multiple components＂,＂pharmacokinetic markers of traditional Chinese medicine＂and＂metabonomics technology＂can resolve this problems,but there are still of a lot of controversy in the present study. This paper organizes the related literature with pharmacokinetics of traditional Chinese medicine in recent 10 years. We hope it can provide reference for the study of pharmacokinetics of traditional Chinese medicines.

关 键 词：中药药代动力学 中药多组分整合药代动力学 中药药代标记物 代谢组学 

分 类 号：R285.5[医药卫生—中药学]