血栓通联合单唾液酸四己糖神经节苷脂治疗2型糖尿病周围神经病变的疗效  

Therapeutic effect of Xueshuantong injection combined with monosialotetrahexosyl ganglioside sodium on diabetic peripheral neuropathy

作　　者：何茜[1] 于瑞萍[1] 

机构地区：[1]贵州省人民医院内分泌科,贵州贵阳550002

出　　处：《包头医学院学报》2016年第7期27-28,共2页Journal of Baotou Medical College

摘　　要：目的:探讨血栓通联合单唾液酸四己糖神经节苷脂治疗2型糖尿病周围神经病变的疗效及安全性。方法:将160例糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)患者分为观察组和对照组各80例,观察组予静脉滴注血栓通500 mg/d和单唾液酸四己糖神经节苷脂钠40 mg/d,对照组仅予静脉滴注单唾液酸四己糖神经节苷脂钠40 mg/d,疗程均为2周。观察治疗后症状改善情况,测定治疗前后、腓总神经的运动神经传导速度(motor nerve conduction velocity,MCV)和感觉神经传导速度(sensory nerve conduction velocity,SCV)。结果:观察组及对照组总有效率分别为91.25%(73/80)、75.00%(60/80),观察组疗效优于对照组(P<0.05)。结论:血栓通联合单唾液酸四己糖神经节苷脂治疗DPN疗效明显,值得临床推广使用。Objective：To evaluate the therapeutic effect and safety of Xueshuantong injection combined with monosialotetrahexosyl ganglioside in the treatment of diabetic peripheral neuropathy （DPN）.Methods：160 cases of patients with DPN were divided into observation group （80 ca-ses） and control group （80 cases）.The patients in the observation group were treated with Xueshuantong injection 500 mg/d combined with mono-sialotetrahexosyl ganglioside sodium 40 mg/d through intravenous drip, and the patients in the control group were only treated with monosialotetra-hexosylganglioside sodium 40 mg/d through intravenous drip.The course of treatment was 2 weeks.All the patients were examined before and after the treatment to measure their motor and sensory nerve conduction velocity （MCV and SCV） of the medial and common peroneal nerves.Results：The overall effect rate in the observation group was 91.25 %（73/80）, which was significantly higher than 75.00 % （60/80） in the control group （ P 〈0.05）.Conclusion：Xueshuantong injection combined with monosialotetrahexosyl ganglioside sodium is effective for treating DPN , worthy of clinical application.

关 键 词：糖尿病周围神经病变 血栓通 单唾液酸四己糖神经节苷脂 

分 类 号：R587.2[医药卫生—内分泌]