不同降压药联合叶酸对伴H型高血压急性脑梗死的疗效研究  

Effect of Different Antihypertensive Drugs Combined With Folic Acid on Acute Cerebral Infarction in Patients With Type H Hypertension

作　　者：康聚贤[1] 张培[1] 尹少华[1] 范志亮[1] 陈欣[1] 

机构地区：[1]邢台市人民医院神经内科,河北邢台100053

出　　处：《中国卫生标准管理》2016年第11期121-122,共2页China Health Standard Management

基　　金：河北省邢台市科技支撑计划项目;编号(2014ZC155)

摘　　要：目的选择不同降压药与叶酸合用,应用于伴H型高血压的急性脑梗死患者,观察疗效。方法将100例急性脑梗死伴H型高血压的患者随机分为两组,A组给予尼莫地平联合叶酸,B组给予依那普利联合叶酸,治疗3周。结果治疗前,两组的基本情况差异无统计学意义(P>0.05)。3周后两组患者的血压、血同型半胱氨酸(Hcy)水平和神经功能缺损评分均低于治疗前(P<0.05),且A组神经功能缺损评分低于B组,差异有统计学意义(P<0.05)。结论两组降压、降血Hcy效果均较好,改善脑损伤方面尼莫地平组疗效更佳。Objective Different antihypertensive drugs and folic acid were used to observe the efficacy of H-type hypertension patients with acute cerebral infarction.Methods100 cases of acute cerebral infarction with H-type hypertension patients were randomly divided into two groups,group A given nimodipine combined with folic acid and group B given enalapril combined with folic acid and 3 weeks of treatment.Results Before treatment,there was no significant difference between the two groups （P〉0.05）. After 3 weeks of two groups of patients with blood pressure and serum homocysteine （Hcy） level and neural function defect score were lower than those before treatment （P〈0.05） and group A of nerve function defect score was lower than that in group B,the difference is statisticaly significant（P〈0.05）. Conclusion Two groups of blood pressure,lowering blood Hcy effect are better,improve the brain damage in Nimodipine group better effect.

关 键 词：降压药 叶酸 H型高血压 急性脑梗死 

分 类 号：R544.1[医药卫生—心血管疾病]