丙肝患者HCV-RNA阳性与自免肝抗体相关性研究  

Correlation Study on HCV-RNA Positive and Liver Autoantibodies for Patients With Hepatitis C

作　　者：马晓慧[1] 

机构地区：[1]河南省人民医院检验科,河南郑州450003

出　　处：《中国卫生标准管理》2016年第11期159-160,共2页China Health Standard Management

摘　　要：目的探讨丙肝患者HCV-RNA阳性感染与自免肝抗体产生的相关性。方法对330例丙肝抗体Ig G(+)患者进行HCV-RNA检测及相关的自免肝抗体检测。结果 330例肝炎患者中,有182例HCV-RNA阳性,阳性率为(55.1%),148例患者HCV-RNA阴性,阴性率为(44.8%)。将其分为两组,第一组:丙肝抗体Ig G(+),HCV-RNA均为阳性,测得AMA-M2阳性13例(7.1%),SLA阳性23例(12.6%),LKM-1阳性40例(22%),LC-1阳性11例(6%);第二组:丙肝抗体Ig G(+),HCV-RNA阴性,测得AMA-M2阳性4例(2.7%),SLA阳性6例(4.1%),LKM-1阳性19例(12.8%),LC-1阳性4例(2.7%)。两组自免肝抗体阳性率差异有统计学意义(χ2=93.4,P<0.05)。结论丙肝患者自免肝抗体检测阳性率与丙肝患者HCV-RNA阳性呈正相关。Objective To investigate the relationship between hepatitis C infection in patients with HCV-RNA positive and liver autoantibodies.Methods 330 cases of hepatitis C antibody IgG（＋）HCV-RNA detection and related liver autoantibodies were detected by spectrum. Results Among 330 cases of hepatitis,182 cases were HCV-RNA positive,the positive rate was （55.1%）,148 cases were HCV-RNA negative,and the negative rate was （44.8%）. Divided into two groups,the first group：HCV IgG（＋）,HCV-RNA were positive,AMA-M2 positive in 13 cases（7.1%）,SLA positive in 23 patients（12.6%）,LKM-1 positive in 40 cases（22%）,LC-1 positive in 11 cases（6%）. The second group： HCV IgG（＋）,HCV RNA negative measured AMA-M2 positive in 4 cases（2.7%）,SLA positive in 6 cases（4.1%）,LKM-1 positive in 19 cases（12.8%）,LC-1 positive in 4 cases （2.7%）. There was significant difference between the two groups in the positive rate of liver autoantibodies（χ2=93.4,P〈0.05）.Conclusion Liver autoantibodies positive rate was positively related to those of HCV-RNA positive rate in hepatitis C patients.

关 键 词：丙肝抗体 HCV-RNA 自免肝抗体 

分 类 号：R512.63[医药卫生—内科学]