陇西县γ-干扰素释放试验检测结核分枝杆菌潜伏感染流行现状及影响因素研究  

Study on the Latent Infection of Mycobacterium Tuberculosis Status Tested by γ-Interferon Release Assays and Analyse the Influencing Factors of Longxi County in Gansu Province

作　　者：杨枢敏[1] 何健[1] 司红艳[1] 辜吉秀[1] 李晴[1] 王雯[1] 陈亚林 栾树茂 何玉珏 高巧芬 赵剑喜[1] 陈威涛[1] 刘芳[1] 王铂[1] 

机构地区：[1]甘肃省疾病预防控制中心,兰州7300002 [2]陇西县疾病预防控制中心,甘肃陇西748100

出　　处：《中国初级卫生保健》2016年第7期61-63,共3页Chinese Primary Health Care

基　　金：科技重大专项"结核病流行与干预模式研究"子课题"结核分枝杆菌感染的流行病学调查和队列研究"(2013ZX10003-004-002)

摘　　要：目的掌握甘肃省陇西县人群γ-干扰素释放试验检测结核分枝杆菌潜伏感染流行病学特征及影响因素。方法通过问卷调查收集研究对象基本信息。采集血液样本,采用γ-干扰素释放试验(IGRA)判定是否结核分枝杆菌潜伏感染。采用SPSS 15.0软件进行数据分析。感染阳性率的比较用χ2检验。对χ2检验中有统计学意义的因素进行二元多因素logistic回归分析。结果本研究5 527例,IGRA阳性957例,结核分枝杆菌潜伏感染率为17.3%。男性结核分枝杆菌潜伏感染率为21.2%,女性结核分枝杆菌潜伏感染率为14.4%,差别有统计学意义(χ2=43.585,P<0.05)。结核分枝杆菌潜伏感染率随着年龄的增大呈线性上升趋势,差异有统计学意义(χ2=545.610,P<0.05)。不同职业间结核分枝杆菌潜伏感染率差异有统计学意义(χ2=395.949,P<0.05)。性别、年龄、职业、吸烟与否、饮酒与否和食用豆制品频率不同情况下,结核分枝杆菌潜伏感染率差异有统计学意义(P<0.05)。logistic回归分析结果显示男性、年龄增大、吸烟为结核分枝杆菌潜伏感染的危险因素。结论通过γ-干扰素释放试验检测5 527例甘肃省陇西县人群,掌握了结核分枝杆菌潜伏感染流行病学特征及影响因素。OBJECTIVE To master the epidemic status of latent infection of mycobacterium tuberculosis tested by IGRA and analyse the influencing factors of Longxi County in Gansu Province. METHODS Using questionnaire to collect basic information about the object of study. Samples determines whether latent infection of mycobacterium tuberculosis. The test datas were analyzed by SPSS 15.0 Software. The positive rates of latent infection were compared by the chi-square test, and then the statistically significant factors were analyzed by Binary Multistage Logistic regression analysis. RESULTS Of all 5 527 cases of subjects, 957 were latent infection positive tested by IGRA assays, the positive rate was 17.3%. In all subjects, the positive rate of male was the positive rate of famale was 14.4%. The positive rates between male and femal were significantly different （χ^2=43.585, P〈0.05） . The latent infection rate of mycobacterium tuberculosis increased with age, and the difference was statistically significant（χ^2=545.610, P〈0.05）. In different occupations, latent infection rates of mycobacterium tuberculosis were significantly different（χ^2=395.949, P〈0.05）. While sex, age, occupation, smoking, drinking and eating soy products frequency were not the same, the latent infection rates of mycobacterium tuberculosis were significantly different（P〈0.05）. Logistic regression analysis result showed that males, older age and smoking were the risk factors of latent infection of mycobacterium tuberculosis. CONCLUSION It detected 5 527 cases subjects of Longxi County in Gansu Province by γ-interferon release assay, mastered the latent infection of mycobacterium tuberculosis epidemiological characteristics and the influencing factors.

关 键 词：结核分枝杆菌 潜伏感染 γ-干扰素释放试验(IGRA) 影响因素 

分 类 号：R521[医药卫生—内科学]