糖尿病的前沿治疗药物与治疗方案  

Frontiers in the Treatment of Diabetes

作　　者：高峰[1] 李利萍[1] 李欢[1] 彭金兰[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院内分泌科,武汉430022 [2]华中科技大学同济医学院附属普爱医院内分泌科,武汉430034

出　　处：《医药导报》2016年第7期679-687,共9页Herald of Medicine

摘　　要：近年来,随着社会的快速发展及人们生活方式的急剧变化,糖尿病患病率逐年上升,2型糖尿病逐渐向青壮年甚至青少年蔓延。传统口服降糖药与胰岛素治疗不能阻止糖尿病病程进展,如血糖长期控制不佳,糖尿病急、慢性并发症相继出现,严重影响健康并为患者带来巨大经济负担。因此,糖尿病的治疗需要引起全社会重视,并采取相应的干预措施。该文着重综述糖尿病新型治疗药物和方案,包括二肽基肽酶-4(DPP4)抑制药、单片复方制剂、胰高血糖素样肽-1(GLP-1)受体激动药、钠-葡萄糖共转运体2(SGLT2)抑制药、胰淀素类似物、多巴胺受体激动药、胆汁酸螯合剂、减重手术,以及胰腺干细胞移植。In recent years,the prevalence of diabetes is increasing year by year with the improvement of people＇s living standard.The traditional oral anti-hyperglycemic drugs as well as insulin injection therapy can not block the progress of the disease course.The deterioration of glycaemic control results in various acute and chronic complications which seriously affect patients＇ health and bring huge economic burden.The researchers have been seeking new therapeutic regimens to improve or even reverse diabetes process.This paper focuses on the following novel treatment options such as GLP-1 receptor agonist,DPP4 inhibitors, fixed-dose combination,SGLT2 inhibitors,amylin analogues,dopamine receptor agonist,bile acid sequestrant,bariatric surgery and pancreatic stem cell transplantation.

关 键 词：二肽基肽酶-4抑制药 胰高血糖素样肽-1受体激动药 钠-葡萄糖共转运体2抑制药 胰淀素类似物 多巴胺受体激动药 糖尿病 减重手术 胰腺干细胞移植 

分 类 号：R977.1[医药卫生—药品] R587.1[医药卫生—药学]