纳米给药系统的抗肿瘤药物联合治疗策略  

Nanoparticle-based Combination Therapies for Cancer Treatment

作　　者：叶鹏[1,2] 张文典[2] 杨坦[2] 盖永康 项光亚[2] 

机构地区：[1]武汉大学人民医院药学部,武汉430060 [2]华中科技大学同济医学院药学院,武汉430030

出　　处：《医药导报》2016年第7期752-757,共6页Herald of Medicine

基　　金：国家自然科学基金资助项目(81503015)

摘　　要：药物联合治疗和纳米给药系统的应用在肿瘤药物治疗领域均展现出广阔的前景。多种治疗药物联用能够同时作用于多个靶点,发挥药物间的协同作用,提高疗效并对抗肿瘤细胞的耐药性。纳米给药系统能够实现药物对肿瘤细胞的靶向传递,提高抗肿瘤效果,降低不良反应,改善患者预后。上述两项治疗策略的融合有望进一步提升药物化学治疗和药物联用的效果。该文介绍近年来纳米给药系统在抗肿瘤药物联合治疗方面的应用情况,并对各种药物联用策略进行分类阐述。Combination chemotherapy and nanoparticle drug delivery are two promising strategies in cancer treatment. The use of multiple therapeutic agents in combination provides synergistic effects among different drugs against cancer cells and suppresses drug resistance through distinct mechanisms of action.Nanocarriers can improve anti-tumor effects of drugs and reduce systemic toxicity through delivering drugs into the tumor tissue specially. Recently, many studies are aiming to encapsulate multiple agents into nanocarriers to optimize the anti-tumor effects. In the present review, the recent advances of nanoparticle platforms applied with co-delivering two or more drugs were summarized and the various combination strategies based on nanoparticles in oncology were discussed.

关 键 词：纳米给药系统 药物联用 肿瘤治疗 多药耐药 协同作用 

分 类 号：R979.1[医药卫生—药品]