移植肾急性排异反应的肾功能声学造影评价  

Characteristics of contrast-enhanced ultrasound of transplanted kidney during acute rejection

作　　者：朱建平[1] 孙立[1] 徐荣全[1] 

机构地区：[1]南京军区福州总医院超声诊断科,福州350025

出　　处：《功能与分子医学影像学（电子版）》2012年第1期38-41,共4页Functional and Molecular Medical Imaging(Electronic Edition)

基　　金：南京军区重大课题(09Z029);南京军区医学科技创新课题(08MA108);南京军区重点课题(10Z030);福建省自然科学基金资助项目(2009J01187)

摘　　要：目的探讨移植肾急性排异(AR)反应的声学造影图像、时间-强度曲线(TIC)以及曲线参数变化的意义。方法采用编码反相脉冲谐波造影技术,观察30例肾功能稳定期、18例AR受检者的造影图像,分析两组受检者造影效果、TIC及曲线参数值之间的差异。结果移植肾AR组,造影剂分布不均,肾轮廓清晰度降低,整个移植肾的造影剂充填较肾功能稳定组稀疏(P<0.05),造影剂上升时间约(12.3±2.05)s,平均通过时间约(65.8±21.6)s、排空时间约(280±23.4)s,TIC第二峰低平与肾功能稳定组比较P<0.05。结论移植肾发生急性排异反应时,造影显影效果、TIC质量不同程度降低,造影剂灌注时间、排空时间延长。Objective To evaluate the changes of contrast-enhanced ultrasound sonogram, time-intensity curve （TIC） and curvilinear indexes of transplanted kidney during acute rejection （AR）. Methods Thirty recipients with stable renal function and 18 recipients with acute rejection were examined using color doppler ultrasonograph. The sonogram of coded pulse inversion imaging （CPI） and the TICs and curvilinear indexes derived from the Sonoliver TIC analysis software were compared. Results When AR happened, distribution of the contrast agent in the kidney became uneven, with mild hypoperfusion and unclear kidney margin. The rise time, mean transmit time and empty time of whole kidney were （12.3 ± 2.05） s, （65.8 ±21.6） s and （280 ± 23.4） s respectively （P 〈 0.05）. TIC waved with a lower or disappeared second peak. Conclusions When acute rejection happens in transplanted kidney, the quality of CEUS appearance and TIC may decrease, accompanied by prolonged curvilinear indexes.

关 键 词：移植肾 声学造影 声学定量 时间-强度曲线 急性排异反应 

分 类 号：R699.2[医药卫生—泌尿科学] R445.1[医药卫生—外科学]