农村血尿酸水平对冠心病影响的临床研究  

Clinical research on the effect of blood uric acid on coronary heart disease in rural area

作　　者：李艳丽 谭绮云 赵演池 刘锦嫦 邹蓉 姚玉霞 

机构地区：[1]广州市增城区石滩镇中心卫生院,广东广州511330

出　　处：《中国医药科学》2016年第9期198-200,219,共4页China Medicine And Pharmacy

基　　金：广东省科技计划项目(20120314)

摘　　要：目的：研究农村血尿酸水平对冠心病影响和意义。方法按是否患有冠心病这一分组标准从2013年12月～2015年12月农村冠心病患者中随机选取72例为观察组，农村健康体检群体中随机选取72例为对照组作为研究对象。比较两组基本临床资料，观察患者血尿酸水平与冠心病之间的联系。并对冠心病患者实施别嘌呤醇进行治疗，观察治疗后对患者冠心病影响情况。结果男性患者体内血尿酸含量显著高于女性，且年龄越大，血尿酸含量越高，差异均有统计学意义（均P＜0.05）。观察组高血压、糖尿病占比显著高于对照组，且观察组患者TC、TG与BMI水平显著高于对照组，差异均有统计学意义（均P＜0.05）。其中高血压、年龄、血尿酸、TC均为影响冠心病的因素。治疗前观察组血尿酸水平显著高于对照组，治疗后无明显差异（P＞0.05）。观察组ABI水平显著低于对照组，治疗后两组无明显差异（P＞0.05）。结论冠心病发病率与农村血尿酸水平呈正相关，高水平血尿酸参与冠心病的发生与发展。临床将血尿酸水平作为治疗的一项，对冠心病的防治具有重要意义。Objective To explore the effect and significance of blood uric acid on coronary heart disease in rural area.Methods 72 patients with coronary heart disease in rural area during December 2013 and December 2015 were randomly selected as observation group, and another 72 healthy individuals in rural area were selected as control group. The basic clinical data of the two groups were studied and compared, the relationship between blood uric acid and coronary heart disease was analyzed. The coronary heart disease patients were treated with allopurinol, which curative effect was analyzed.Results The blood uric acid levels of male patients were obviously higher than those of female patients, and the blood uric acid level had a positive correlation with patients＇ age, the differences were statistically significant （P〈0.05）. In the observation group, the proportions of hypertension and diabetes mellitus, as well as patients＇ TC, TG, and BMI were obviously higher than those of the control group, the differences were statistically significant （P〈0.05）, and the hypertension, age, blood uric acid, and TC were all influencing factors of coronary heart disease. Before treatment, in the observation group, the blood uric acid was obviously higher and the ABI was obviously lower than those of the control group, after treatment, there were no obvious differences （P〉0.05）. Conclusion There is a positive correlation between incidence of coronary heart disease and blood uric acid levels of patients in rural area, high blood uric acid level evokes and promotes the coronary heart disease. Controlling blood uric acid level in clinical practice is very important for the prevention and treatment of coronary heart disease.

关 键 词：血尿酸 冠心病 嘌呤醇 ABI 

分 类 号：R541.4[医药卫生—心血管疾病]