Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae  

作　　者：SONG Jing E SI Jing ZHOU Rong LIU Hua Peng WANG Zhen Guo GAN Lu GUI Fang LIU Bin ZHANG Hong 

机构地区：[1]School/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, Gansu, China [2]Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China [3]Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China [4]Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, Gansu, China [5]Gansu Medicinal College, Pingliang 744000, Gansu, China [6]Lanzhou veolia Water(Group) Co., Ltd, Lanzhou 730000, Gansu, China

出　　处：《Biomedical and Environmental Sciences》2016年第6期453-456,共4页生物医学与环境科学（英文版）

基　　金：supported by National Basic Research Program of China(2010CB834202);the National Natural Science Foundation of China(11305226,11175222);the Scientific Technology Research Projects of Lanzhou City(2015-3-75);the Western Talent Program of Chinese Academy of Sciences(Y460030XB0)

摘　　要：The use of exogenous carbon monoxide releasing molecules（CORMs）provides promise for clinical application;however,the hazard potential of CORMs in vivo remains poorly understood.The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to400μmol/L during 4-144 h post fertilization.Toxicity endpoints of mortality,spontaneous movement,heart rate,hatching rate,malformation,body length,and larval behavior were measured.The use of exogenous carbon monoxide releasing molecules（CORMs）provides promise for clinical application;however,the hazard potential of CORMs in vivo remains poorly understood.The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to400μmol/L during 4-144 h post fertilization.Toxicity endpoints of mortality,spontaneous movement,heart rate,hatching rate,malformation,body length,and larval behavior were measured.

关 键 词：CO Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae 

分 类 号：R114[医药卫生—卫生毒理学]