急性冠脉综合征非手术治疗患者血清尿酸及B型纳尿肽水平与GRACE评分的相关性及其预测价值  

Correlation between serum uric acid/BNP levels and GRACE score in patients with acute coronary syndrome and its predictive value

作　　者：刘京锋[1] 汪钰[1] 王学东[1] 

机构地区：[1]北京市和平里医院CCU病房,北京100013

出　　处：《实用医院临床杂志》2016年第4期67-69,共3页Practical Journal of Clinical Medicine

摘　　要：目的探讨非手术治疗的急性冠脉综合征(acute coronary syndrome,ACS)患者的血清尿酸(UA)及B型钠尿肽(BNP)水平与全球急性冠状动脉事件注册(GRACE)评分的相关性及对远期预后的预测价值。方法未行手术治疗的ACS患者291例,入院后立即测定其血清尿酸及BNP水平,根据GRACE评分将患者分为高危组95例、中危组121例和低危组75例,随访发病6个月的主要心血管不良事件(MACE)的发生情况,分析UA、BNP水平与GRACE评分间的相关性及三者对MACE发生的预测价值。结果高危组UA及BNP高于中危组及低危组,差异有统计学意义(P<0.01),UA、BNP均与GRACE评分呈线性正相关。结论非手术治疗的ACS患者血清UA及BNP水平与GRACE评分呈正相关;血清UA、BNP水平及GRACE评分可有效预测MACE的发生风险。Objective To investigate the relationship between levels of serum uric acid /B-type natriuretic peptide （ BNP） and global registry of acute coronary events （ GRACE） risk score in patients with acute coronary syndrome （ ACS） and their predictive value for long-term prognosis.Methods The serum uric acid,BNP and GRACE were measured in 291 patients who were diagnosed as ACS and not treated by surgery .The main adverse cardiovascular events （ MACE） were followed up for a six mouths .The correlation between serum levels of uric acid/BNP and GRACE scores was analyzed .The predictive value of MACE was evaluated as well .Results Ac-cording to GRACE score ,ACS patients were divided into high ,medium and low risk groups .Serum uric acid and BNP levels in high risk group were significantly higher than that in another 2 groups （ P〈0.01 ） .The levels of serum uric acid and BNP were both linearly cor-related with GRACE scores .Conclusion In ACS patients without surgical treatment ,the higher levels of serum uric acid and BNP are , the higher the GRACE scores are .Serum levels of uric acid/BNP and GRACE scores are positively correlated with the risk of MACE .

关 键 词：急性冠脉综合征 尿酸 BNP GRACE评分 

分 类 号：R541.4[医药卫生—心血管疾病]