急性肾损伤患者NT-proBNP与血管外肺水指数相关性研究  

Association between plasma NT-proBNP and extravascular lung water index in patients with acute kidney injury

作　　者：谢晓红[1] 麦叶[1] 魏晓芬[1] 周忠义[1] 李娜[1] 李瑞[1] 

机构地区：[1]海南省人民医院重症医学科,海口570311

出　　处：《检验医学与临床》2016年第13期1769-1771,共3页Laboratory Medicine and Clinic

基　　金：2014年海南省科委自然科学基金项目(814321)

摘　　要：目的探讨接受机械通气治疗的急性肾损伤(AKI)患者血浆N末端B型钠尿肽前体(NT-proBNP)水平动态变化与血管外肺水指数(EVLWI)的相关性。方法将80例接受机械通气及连续性肾脏替代治疗(CRRT)的AKI患者分为A、B、C组,各组血清肌酐(SCr)水平依次升高、尿量依次降低。分别在CRRT治疗前及治疗后12、24、72h检测血浆NT-proBNP、SCr水平及EVLWI的水平,分析其间相关性。结果各组患者治疗前APACHEⅡ评分、SCr水平比较差异有统计学意义(P<0.05)。SCr、NT-proBNP、EVLWI水平随CRRT治疗时间延长呈下降趋势。各组患者CRRT治疗后72h上述指标检测结果与治疗前比较差异有统计学意义(P<0.05),各组间相同时间点各指标检测结果比较差异有统计学意义(P<0.05)。各组患者CRRT治疗前及治疗后12、24、72h血浆NT-proBNP水平与SCr、EVLWI呈正相关(P<0.05)。结论 AKI患者血浆NT-proBNP水平与EVLWI具有良好的相关性。Objective To discuss correlation between plasma N‐terminal B‐type atriuretic peptide precursor （NT‐proBNP） and extravascular lung water index （EVLWI） in patients with acute kidney injury （AKI） received mechanical ventilation .Methods A to‐tal of 80 AKI patients receiving mechanical ventilation and continuous renal replacement therapy （CRRT ） were divided into A ,B and C group ,of which serum creatinine（SCr） level gradually inreased and urinve volume decreased .Plasma NT‐proBNP ,SCr and EVL‐WI were detected before and 12 ,24 ,72 h after CRRT .Results APACHEⅡ score and SCr level were significantly different between all groups （P〈0 .05） .SCr ,NT‐proBNP and EVLWI levels gradually decreased aftar CRRT ,values of which ,detected 72 h after CRRT ,were lower than values detected before CRRT （P〈0 .05） .The difference between the groups was statistically significant at the same period（P〈0 .05） .Before and 12 ,24 ,72 h after CRRT ,plasma NT‐proBNP were positively correlated with SCr and EVL‐WI（P〈0 .05） .Conclusion Plasma NT‐proBNP and EVLWI might have correlation in AKI patients .

关 键 词：连续性肾脏替代治疗 急性肾损伤 N末端B型钠尿肽前体 血管外肺水指数 预后 

分 类 号：R541.63[医药卫生—心血管疾病]