变应性鼻炎患者主要鼻部症状与体内组胺及白三烯D4含量的相关性研究  

The relationship between the key nasal symptoms and the level of histamine and leukotriene D4 in serum and nasal secretions in allergic rhinitis

作　　者：张鑫雨[1] 申聪香[1] 文忠[1] 李冠雪[1] 王会刚[1] 陈芳[1] 

机构地区：[1]南方医科大学珠江医院耳鼻咽喉头颈外科,广州510282

出　　处：《临床耳鼻咽喉头颈外科杂志》2016年第13期1025-1028,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨变应性鼻炎(AR)患者主要鼻部症状与血清和鼻分泌物中组胺及白三烯D4(LTD4)含量的相关性,为AR的个体化治疗开辟新领域。方法:选取2014-01-2015-06期间收治的108例AR患者,按主要鼻部症状评分(喷嚏、流涕等)分成组胺症状组(喷嚏组)及白三烯症状组(鼻塞组),采用ELISA法测定AR患者血清和鼻分泌物中组胺和LTD4含量,分析症状与组胺及LTD4水平的相关性。结果:AR患者喷嚏积分为5.58±2.59,与血清和鼻分泌物中的组胺含量均呈正相关(r=0.79、0.78,均P<0.05),但与LTD4无明显相关性。鼻塞积分为5.34±2.36,与血清和鼻分泌物中的LTD4含量均呈正相关(r=0.74、0.72,均P<0.05),与组胺无明显相关性。血清中组胺及LTD4含量为(8.39±4.07)ng/ml和(0.356±0.155)ng/ml,分别与鼻分泌物中二者含量[(5.06±2.47)ng/ml及(0.215±0.092)ng/ml]呈正相关(r=0.99、0.98,均P<0.01)。结论:AR患者血清和鼻分泌物中的组胺水平升高与喷嚏组症状呈现高度一致性变化,血清和鼻分泌物中LTD4的含量升高与鼻塞组症状呈现高度一致性变化。Objective：To investigate the relationship between main nasal symptoms and the levels of histamine and leukotriene D4（LTD4）in serum and nasal secretions in allergic rhinitis（AR）,and provide a preliminary guidance for individualized treatment in AR.Method：One hundred and eight cases of AR were divided into two groups,i.e.sneezing group and nasal congestion group,according to 2014 clinical guidelines for allergic rhinitis from January 2014 to June 2015.The levels of histamine and LTD4 in serum and nasal secretions were determined by enzyme-linked immunosorbent assay（ELISA）and the relationship was explored between the clinical main nasal symptoms score and the levels of histamine and LTD4.Result：The scores of sneezing（5.58±2.59）for AR were obviously related to the levels of histamine in serum（8.39±4.07）ng/ml and nasal secretion（5.06±2.47）ng/ml,（r=0.79,0.78,all P〈0.05）.The scores of nasal congestion（5.34±2.36）for AR were also related to the levels of LTD4 in serum（0.356±0.155ng/ml）and nasal secretion（0.215±0.092）ng/ml,（r=0.74,0.72,all P〈0.05）.And the levels of histamine（8.39±4.07）ng/ml and LTD4（0.356±0.155）ng/ml in serum for AR patients were positively correlated with the levels in nasal secretions（r=0.99,P〈0.01;r=0.98,P〈0.01）.Conclusion：In AR patients,the high levels of histamine and LTD4 in serum and nasal secretions are closely related to the sneezing symptoms and nasal obstruction symptoms,respectively.

关 键 词：鼻炎 变应性 组胺 白三烯 相关性 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]