NT-proBNP水平对非ST段抬高型急性冠脉综合征危险分层价值的研究  

Study of NT-pro BNP in the risk stratification value of non-ST segment elevation acute coronary syndrome

作　　者：刘杰[1] 王锋[1] 闫兴国[1] 吴秀明[1] 

机构地区：[1]江苏省丰县人民医院心内科,江苏丰县221700

出　　处：《中国现代医生》2016年第16期24-26,F0003,共4页China Modern Doctor

摘　　要：目的探讨血液中N末端B型利钠肽原（NT-proBNP）对非ST段抬高型急性冠状动脉综合征（NSTE-ACS）危险分层的价值。方法选取2012年1月～2013年12月间我科94例NSTE-ACS患者分为高危NSTE-ACS组52例（高危UAP22例，NSTEM130例）和非高危NSTE-ACS组42例[f氐危UAP20例，中危UAP22例】；将具有胸痛症状且经冠状动脉cT造影（CCTA）证实为阴性的患者为对照组，共38例。入院后即刻采集静脉血同时检测NT-proBNP、高敏肌钙蛋白T（hs-cTnT）浓度，比较各组间NT-proBNP、hs-cTnT浓度的变化，并分析其相关性。结果高危NSTE-ACS组NT-proBNP、hs-cTnT浓度均高于非高危NSTE-ACS组，差异有统计学意义（P〈0．01），经Pearson直线相关分析，高危NSTE-ACS组NT-proBNP浓度与hs-cTnT浓度呈正相关（r：=0．92，P〈0．001）；非高危NSTE-ACS组NT-proBNP浓度与hs-cTnT浓度亦呈正相关（r=0．83，P〈0．001）。结论NT-proBNP是心肌缺血损伤的可靠指标，可作为NSTE-ACS危险分层的依据。Objective To study of the N-terminal pro-brain B-type natriuretic peptide （NT-proBNP）in the risk stratifi cation value of non-ST segment elevation acute coronary syndrome （NSTE-ACS ACS）. Methods 94 patients with NSTE-ACS in January 2012 to December 2013 were divided into high-risk NSTE-ACS group （52 patients） including 22 patients with high-risk unstable angina pectoris （high-risk UAP）, 30 patients with non-ST segment elevation acute myocardial infarction（NSTEMI）,and non-high-risk NSTE-ACS group（42 patients） including 20 patients with low-risk UAP and 22 patients with middle-risk UAP; 38 patients with noncardiac chest pain by coronary computed tomography angiography （CCTA） was control group. By collecting venous blood and detecting concentration of NT-proBNP and high sensitive troponin T（hs-cTnT） of patients with NSTE-ACS, concentration of NT-proBNP and hs-cTnT of patients with NSTE-ACS in each group was compared and their correlation was analyzed. Results Concentration of NT-proB- NP and hs-cTnT was higher in high-risk NSTE-ACS group than in non-high-risk NSTE-ACS group （P〈0.001）; con- centration of NT-proBNP positively correlated with hs-cTnT level in high-risk NSTE-ACS group（r=0.92,P〈0.001） by Pearson rectilinear correlation analysis,so in non-high-risk NSTE-ACS group （r=0.83 ,P〈0.001）. Conclusion NT- proBNP is reliable indicator of myocardial ischemia and injury, and is on the basis of risk stratification in patients with NSTE-ACS.

关 键 词：非ST段抬高型急性冠状动脉综合征 N末端B型利钠肽原 高敏心肌肌钙蛋白 冠心病 危险分层 

分 类 号：R541.4[医药卫生—心血管疾病]