2型糖尿病患者轻度认知功能障碍与微量蛋白尿相关性的研究  

Research on relationship between mild cognitive impairment and albu-minuria among type 2 diabetic patients

作　　者：林广君[1] 罗冬冬[2] 

机构地区：[1]大连医科大学附属第二医院神经内科,辽宁大连116023 [2]大连医科大学附属第二医院内分泌科,辽宁大连116023

出　　处：《中国现代医生》2016年第16期27-29,共3页China Modern Doctor

摘　　要：目的探讨2型糖尿病患者的认知功能损害与蛋白尿之间关系。方法203例患者根据尿微量白蛋白／肌酐比值分为三组。UALB／Cr〈30mg／g为A组；UALB／Cr在（30-300）mg／g之间为B组；UALB／Cr〉300mg／g为C组，采用蒙特利尔认知评估量表（MoCA）对三组患者进行认知功能评估。结果①三组患者MCI的发病率分别为5．33％、11．77％、28．33％，三组间比较差异有统计学意义（P〈0．01）；②三组MoCA总分比较，差异有统计学意义（P〈0．01或P〈O．05），三组间的视空间与执行功能、语言流畅、延迟记忆比较差异有统计学意义（P〈0．01或P〈0．05）。结论蛋白尿患者存在视空间与执行功能、语言流畅、延迟记忆等方面的认知功能损害。Objective To identify the relationship between mild cognitive impairment and microalhuminuria among type 2 diabetic patients. Methods A total of 203 patients were divided into three groups according to microalbuminuria/ere- atinine ratio, UALB/Cr〈30 mg/g as group A; UALB/Cr between 30 mg/g and 300 mg/g as group B; UALB/Cr〉300 mg/g as group C, Make evaluation of cognitive function for three groups of patients with adoption of Montreal cognitive as- sessment scale（MoCA）. Results （1）Incidences of MCI among three groups are 5.33%, 11.77% and 28.33% respectively, the differences among three groups have statistical significance（P〈0.01 ）; （2）The total scores of MoCA among three groups have statistical significance（P〈0.01 or P〈0.05）; The difference of visuospatial/executive,language and delayed recall have statistical significant （P〈0.01 or P〈0.05）. Conclusion Patients with proteinuria have cognitive impairments in vi- suospatial/executive, language, delayed recall and other aspects.

关 键 词：2型糖尿病 轻度认知功能障碍 蛋白尿 痴呆 

分 类 号：R587.2[医药卫生—内分泌] R749.2[医药卫生—内科学]