支气管哮喘患儿血清中白细胞介素25，33及嗜酸细胞趋化因子水平变化及临床意义  

Interleukin-25, -33 and Eotaxin in the serum of children with bronchial asthma

作　　者：闫静静[1] 林荣军[1] 胡素娟[1] 路玲[1] 

机构地区：[1]青岛大学附属医院,山东省青岛市266000

出　　处：《中国组织工程研究》2016年第B05期156-158,共3页Chinese Journal of Tissue Engineering Research

摘　　要：背景：白细胞介素25，33及嗜酸细胞趋化因子在支气管哮喘发病中起重要作用。目的：观察哮喘儿童血清中白细胞介素25，33及嗜酸细胞趋化因子的表达。方法：随机选取于青岛大学附属医院门诊就诊的轻中度哮喘患儿80例为对象，其中急性发作组42例，临床缓解组38例，同时选取健康儿童30例作对照。结果与结论：哮喘急性期与缓解期、哮喘缓解期与健康对照组之间血清白细胞介素25，33及嗜酸细胞趋化因子水平差异均有显著性意义（P〈0．01）。在哮喘急性期、缓解期血清白细胞介素25，33及嗜酸细胞趋化因子的表达呈正相关（P〈0．05）。哮喘急性期、缓解期血清白细胞介素25，33及嗜酸细胞趋化因子水平与第一秒用力呼出量占肺活量百分比（FEV1％）及最大呼气流量占正常预计值的百分比（PEF％）呈负相关（P〈0．05）。结果说明，支气管哮喘患儿血清白细胞介素25，33及嗜酸细胞趋化因子表达均增高，说明3者均参与了哮喘的发生，参与了哮喘的气道变态反应性炎症的发生。BACKGROUND： Interleukin （IL）-25, -33 and Eotaxin play an important role in pathogenesis of bronchial asthma. OBJECTIVE： To observe the changes in IL-25, IL-33 and Eotaxin in the serum of children of bronchial asthma. METHODS： Eighty children with mild to moderate bronchial asthma were included and assigned into acute attack （n=42）, clinical remission （n=38） groups, and 30 healthy children were selected as normal control. RESULTS AND CONCLUSION： There were significant differences in serum IL-25, IL-33 and Eotaxin between acute attack and clinical remission groups, remission and healthy control groups （P 〈 0.01）. Serum IL-25, IL-33 correlated positively with Eotaxin in children with acute attack and clinical remission （P 〈 0.05）. Serum IL-25, IL-33 and Eotaxin correlated negatively with FEV1% and PEF% in children with acute attack and clinical remission. In conclusion, serum levels of IL-25, IL-33 and Eotaxin are involved in the pathogenesis and allergic asthmatic airway inflammation of bronchial asthma because of the increase of them.

关 键 词：组织工程 支气管哮喘 儿童 白细胞介素25 白细胞介素33 嗜酸 细胞趋化因子 

分 类 号：R692.5[医药卫生—泌尿科学]