肥胖并发高脂血症患者肥胖和“脂肪-胰岛轴”指标的年龄差异  

Age difference of patients with obesity complicated with hyperlipidemia in the indicators related to obesity and fat-islet axis

作　　者：闫利敏[1] 刘志诚[1] 徐斌[1] 卢圣锋[1] 

机构地区：[1]南京中医药大学国家重点省部共建针药结合实验室,江苏省210023

出　　处：《江苏医药》2016年第12期1341-1343,共3页Jiangsu Medical Journal

基　　金：国家自然科学基金(81303019;30873307)

摘　　要：目的分析肥胖并发高脂血症患者肥胖和＂脂肪-胰岛轴＂指标的年龄差异。方法肥胖并发高脂血症患者664例按年龄分为三组：A组224例,〈30岁;B组212例,30~40岁;C组228例,〉40岁。比较三组肥胖指标（体重、肥胖度、BMI、体脂百分率）、脂质指标（TC、TG、LDL-C、HDL-C）、＂脂肪-胰岛轴＂指标[FBG、空腹胰岛素、空腹瘦素（FLP）、胰岛素敏感性指数（ISI）、HOMA-IR和胰岛β细胞功能指数（HOMA-β）]以及植物神经功能指数。结果A组和B组体脂百分率、FBG、HOMA-IR均较C组降低（P〈0.05或P〈0.01）,ISI较C组升高（P〈0.05或P〈0.01）;A组肥胖度、BMI、FLP较C组降低（P〈0.05）;B组HOMA-β较C组升高（P〈0.05）。结论肥胖并发高脂血症患者的年龄与肥胖、＂脂肪-胰岛轴＂指标均密切相关。Objective To explore the age difference of patients with obesity complicated with hyperlipidemia in the indicators related to obesity and fat-islet axis. Methods A total of 664 patients with obesity complicated with hyperlipidaemia was divided into three groups of A（〈30 years old, 224 cases） ,B（30-40 years old, 212 cases） and C（〉40 years old, 228 cases）. The indicators of obesity, lipids, fat-islet axis and autonomic nerve function were compared among three groups. Results The body fat percentage, fasting blood glucose and homeostasis model assessment of insulin resistance index （HOMA-IR） were lower, while insulin sensitive index was higher, in groups of A and B than those in group C（P〈0.05 or P〈0.01）. Obesity degree, body mass index and fasting leptin were lower in group A than those in group C（P〈0. 05）. Homeostasis model assessment of pancreatic β cell function index （HOMA-β） was higher in group B than that in group C（P〈0.05）. Conclusion Age is closely related to the indicators of obesity and fat-islet axis in the patients with obesity complicated with hyperlipidemia.

关 键 词：肥胖 高脂血症 年龄 脂肪-胰岛轴 

分 类 号：R589[医药卫生—内分泌]