IVIM扩散加权成像对多发性肌炎和皮肌炎的诊断价值  

Value of intravoxel incoherent motion diffusion weighted imaging in the diagnosis of polymyositis and dermatomyositis

作　　者：丁宁宁 孟岩[2] 麻少辉[1] 刘本寅 高丽[4] 李小明[4] 

机构地区：[1]西安交通大学第一附属医院医学影像科,西安710061 [2]西安交通大学附属红会医院头颈外科,西安710054 [3]西安交通大学附属红会医院CT室,西安710054 [4]华中科技大学同济医学院附属同济医院放射科,武汉430030

出　　处：《放射学实践》2016年第7期649-653,共5页Radiologic Practice

摘　　要：目的:探讨体素内不相干运动扩散加权成像(IVIM-DWI)技术在多发性肌炎和皮肌炎中的诊断价值。方法:对10例经肌肉活检证实的多发性肌炎和皮肌炎患者(病患组)及11例健康志愿者(正常对照组)进行双侧大腿轴位T1WI、T2STIR和IVIM-DWI扫描,经后处理分析和测量得到IVIM参数值:快速弥散系数(ADCfast值)、慢速弥散系数(ADCslow值)、快速弥散分数(Ff值)。采用单因素方差分析比较各组间参数值差异。结果:病患组水肿肌肉、未受累肌肉(T2STIR上未显示水肿)及正常对照组正常肌肉ADCslow分别(1.59±0.26)、(1.41±0.24)、(1.34±0.13)×10-3 mm2/s,差异有统计学意义(P<0.05),各组ADCfast分别为(10.83±2.69)、(9.09±1.55)、(7.48±2.73)×10-3 mm2/s,差异有统计学意义(P<0.05),其中病患组未受累肌肉ADCfast值高于正常肌肉,差异有统计学意义(P<0.05)。各组Ff值差异无统计学意义(P>0.05)。结论:IVIM-DWI技术可用于定量评估肌肉水分子扩散及微血管灌注情况,ADCslow和ADCfast值对多发性肌炎和皮肌炎的诊断具有重要作用,其中ADCfast值对其早期诊断有意义。Objective：To study the value of intravoxel incoherent motion diffusion weighted imaging（IVIM-DWI）in the diagnosis of patients with polymyositis（PM）and dermatomyositis（DM）.Methods：Ten patients with PM/DM proven by muscle biopsy（patient group）and eleven healthy volunteers（control group）were enrolled in this study.Axial views with IVIM-DWI,T1 WI and T2 STIR sequences were performed on bilateral thighs of all subjects.The IVIM parameters after post-processing included ADCfast,ADCslow,and fraction of ADCfast（Ff）were measured.One-way analysis of variance was used for statistical analyses.Results：The mean ADCslowof edematous muscle,unaffected muscle（no edema on T2STIR）in the patient group and normal muscle in control group was（1.59±0.26）、（1.41±0.24）、（1.34±0.13）×10-3 mm2/s respectively,with statistic difference（P〈0.05）.The mean ADCfastvalue of the three groups mentioned above was（10.83±2.69）、（9.09±1.55）、（7.48±2.73）×10-3 mm2/s respectively,with statistic difference（P〈0.05）.The ADCfastvalue of unaffected muscle in patient group was higher than that of normal group,with statistic difference（P〈0.05）.There was no statistically significant difference among the Ff values of the three groups（P〉0.05）.Conclusion：IVIM-DWI technique could be used to quantitatively evaluate the H2 O diffusion and microcirculation of muscles,ADCslowand ADCfastvalues provided important diagnostic information for patients with PM/DM,especially,ADCfastis valuable in early diagnosis.

关 键 词：多发性肌炎 皮肌炎 扩散加权成像 体素内不相干运动 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R685[医药卫生—诊断学]