间苯三酚联合帕瑞昔布治疗经尿道前列腺电切术后膀胱痉挛的临床研究  

Phloroglucinol combined with parecoxib for cystospasm after transurethral resection of the prostate

作　　者：程顺花[1] 粘烨琦[1] 丁茂[1] 胡善彪[1] 何海填[2] 李玲[1] 王荫槐[1] 

机构地区：[1]中南大学湘雅二医院泌尿外科,湖南长沙410011 [2]深圳市蛇口人民医院泌尿外科,广东深圳518000

出　　处：《中华男科学杂志》2016年第7期641-644,共4页National Journal of Andrology

摘　　要：目的:观察间苯三酚联合帕瑞昔布治疗经尿道前列腺电切术(TURP)后膀胱痉挛的有效性与安全性。方法:采用前瞻性随机病例对照的方法进行研究,纳入接受TURP的患者98例,随机分为试验组与对照组。试验组50例,术后连续3 d予以间苯三酚联合帕瑞昔布治疗(间苯三酚80 mg,1次/d+帕瑞昔布40 mg,2次/d);对照组48例,单独予以间苯三酚80 mg治疗。观察并记录两组患者住院期间出现膀胱痉挛的次数、持续时间、疼痛视觉模拟评分(VAS)及不良反应,同时记录术后膀胱冲洗转淡时间、术后导尿管留置时间及术后住院时间。结果:试验组术后3 d内膀胱痉挛发作次数[(0.70±0.65)次vs(1.95±0.41)次]、膀胱痉挛持续时间[(0.12±0.14)min vs(0.44±0.21)min]、VAS痛觉评分[(1.90±1.30)分vs(2.70±1.80)分]均显著低于对照组(P均<0.01),但两组术后膀胱冲洗转淡时间[(2.64±0.83)d vs(2.75±0.87)d]、术后导尿管留置时间[(3.44±0.42)d vs(3.52±0.32)d]及术后住院时间[(5.10±0.73)d vs(5.23±0.81)d]比较无统计学差异(P均>0.05)。试验组与对照组均未发现明显不良反应。结论:与间苯三酚单药治疗相比,间苯三酚联合帕瑞昔布可更有效地缓解TURP术后膀胱痉挛,并且无明显并发症发生。Objective ： To evaluate the effect and safety of phloroglucinol combined with parecoxib on cystospasm after transure- thral resection of the prostate （TURP）. Methods： We conducted a prospective randomized case-control study on 98 patients treated by TURP. After operation, the patients were randomly assigned to a treatment （n = 50） and a control group （n = 48 ）, the former trea- ted by intravenous injection of 80 mg phloroglueinol qd plus 40 mg parecoxib bid while the latter given 80 mg phloroglucinol only, both for 3 successive days. Then we recorded the frequency and duration of cystospasm, visual analogue scales （VAS） , adverse reactions, post-operative bladder irrigation time, catheter-indwelling time, and hospital stay and compared them between the two groups of pa- tients. Results ： Compared with the controls, the patients in the treatment group showed a significantly lower frequency of cystospasm （ [ 1.95 ±0. 14] vs [ 0.70 ± 0.65 ] times, P 〈 0.01）, duration of cystospasm （ [ 0.44 ±0.21 ] vs [ 0. 12 ± 0. 14 ] min, P 〈 0. 01 ）, and VAS score （2.70 ±1.80 vs 1.90 ±1.30, P 〈0.01 ） at 48 -72 hours after TURP, but no statistically significant differences were found between thecontrol and treatmem groups in the post-operative bladder irrigation time （ [ 2.75 ± 0.87 ] vs [ 2.64 ± 0.83 ] d, P 〉 0.05）, catheter-indwelling time （[3.52 ±0. 32] vs [3.44 ±0. 42] d, P 〉0.05）, and hospital stay （[5.23 ±0.81] vs [5.10 ±0.73] d, P 〉0.05）, and no obvious ad- verse reactions were observed in either of the two groups. Conclusion ： Phloroglucinol combined with parecoxib is more effective and safer than phloroglucinol alone in relieving postoperative cystospasm after TURP.

关 键 词：良性前列腺增生 间苯三酚 帕瑞昔布 经尿道前列腺电切术 膀胱痉挛 

分 类 号：R699[医药卫生—泌尿科学] R694[医药卫生—外科学]