血管损伤的新靶点：干扰素调节因子  

Interferon Regulatory Factor:a New Target for Treating Vascular Injury

作　　者：孔鹏[1] 韩梅[1] 

机构地区：[1]河北医科大学基础医学院,生物化学与分子生物学教研室,河北省医学生物技术重点实验室,石家庄050017

出　　处：《中国生物化学与分子生物学报》2016年第7期763-767,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.91439114,31471092,31271222)资助~~

摘　　要：内膜增生是血管损伤后动脉重塑过程中普遍存在的现象。血管平滑肌细胞(vascular smooth muscle cells,VSMCs)的增殖、迁移、表型转换是血管损伤性疾病高血压、动脉粥样硬化、血管成形术后再狭窄等的共同病理生理学过程。干扰素调节因子(interferon regulatory factors,IRFs)是一类能对干扰素基因表达起到免疫调节作用的转录因子。近来研究发现,其在血管损伤病理过程具有调节作用,其中IRF1与细胞生长、分化和损伤密切相关,IRF3与IRF7可以抑制新生内膜的形成,而IRF8和IRF9则促进VSMCs增殖、迁移及血管内膜增生。本文重点介绍了IRFs的结构特征、信号途径及在血管重塑过程中作为新型调控因子的功能。Intimal hyperplasia is a common phenomenon in the processes of vascular remodeling after injury.The proliferation,migration and phenotypic modulation of vascular smooth muscle cells（VSMCs）are considered to be key events in the pathophysiological development of vascular disorders,such as atherosclerosis,hypertension and restenosis.The interferon regulatory factors（IRFs） are originally discovered as a set of transcription factors that regulate the expression of interferon gene.Recent studies have demonstrated that IRFs are involved in the regulation of pathological processes of vascular injuries.It was known that IRF1 was related to the cell growth,differentiation and injury.IRF3 and IRF7 inhibited the neointimal formation;whereas IRF8 and IRF9 promote VSMC proliferation,migration and the neointimal formation.This review focused on the structural characteristics,signal pathways and functions of IRFs,and discussed the perspective of IRF as a new regulatory factor in the pathological process of vascular remodeling.

关 键 词：干扰素调节因子 信号途径 血管损伤 

分 类 号：R34[医药卫生—基础医学]