Simultaneous acquisition of multi-nuclei enhanced NMR/MRI by solution-state dynamic nuclear polarization  

作　　者：Yugui He Zhen Zhang Jiwen Feng Chongyang Huang Fang Chen Chaoyang Liu Maili Liu 

机构地区：[1]State Key Laboratory of Magnet Resonance and Atomic and Molecular Physics,Wuhan Institute of Physics and Mathematics,Chinese Academy of Sciences,Wuhan 430071,China [2]School of Optical and Electronic Information,Huazhong University of Science and Technology,Wuhan 430074,China [3]University of Chinese Academy of Sciences,Beijing 100048,China

出　　处：《Science China Chemistry》2016年第7期830-835,共6页中国科学（化学英文版）

基　　金：supported by the Chinese Academy of Sciences(ZDYZ2010-2);the Ministry of Science and Technology of China (2011YQ120035);the National Natural Science Foundation of China (11405264,11274347,21221064,11575287)

摘　　要：Dynamic nuclear polarization （DNP） has become a very important hyperpolarization method because it can dramatically increase the sensitivity of nuclear magnetic resonance （NMR） of various molecules. Liquid-state DNP based on Overhauser effect is capable of directly enhancing polarization of all kinds of nuclei in the system. The combination of simultaneous Overhauser multi-nuclei enhancements with the multi-nuclei parallel acquisitions provides a variety of important applications in both MR spectroscopy （MRS） and image （MRI）. Here we present two simple illustrative examples for simultaneously enhanced multi-nuclear spectra and images to demonstrate the principle and superiority. We have observed very large simultaneous DNP enhancements for different nuclei, such as XH and 23Na, 1H and 31p, 19F and 31p, especially for the first time to report sodium ion enhancement in liquid. We have also obtained the simultaneous images of 19H and 31p, 19F and 31p at low field by solution-state DNP for the first time.Dynamic nuclear polarization(DNP) has become a very important hyperpolarization method because it can dramatically increase the sensitivity of nuclear magnetic resonance(NMR) of various molecules.Liquid-state DNP based on Overhauser effect is capable of directly enhancing polarization of all kinds of nuclei in the system.The combination of simultaneous Overhauser multi-nuclei enhancements with the multi-nuclei parallel acquisitions provides a variety of important applications in both MR spectroscopy(MRS) and image(MRI).Here we present two simple illustrative examples for simultaneously enhanced multi-nuclear spectra and images to demonstrate the principle and superiority.We have observed very large simultaneous DNP enhancements for different nuclei,such as ~1H and ^(23)Na,~1H and ^(31)P,^(19)F and ^(31)P,especially for the first time to report sodium ion enhancement in liquid.We have also obtained the simultaneous images of ^(19)H and ^(31)P,^(19)F and ^(31)P at low field by solution-state DNP for the first time.

关 键 词：dynamic nuclear polarization Overhauser effect simultaneous acquisition phosphorous and sodium ion DNP spectra phosphorous DNP image 

分 类 号：O657.2[理学—分析化学]