基于4-氨基奎宁的离子液体在Knoevenagel缩合反应中的应用  

4-amine Quinine Based Ionic Liquid: an Efficient Catalyst for Knoevenagel Condensation

作　　者：高晓冲[1] 马友光[1] 高瑞昶[1] 

机构地区：[1]天津大学化工学院,天津300072

出　　处：《福建师范大学学报（自然科学版）》2016年第4期61-66,共6页Journal of Fujian Normal University：Natural Science Edition

摘　　要：以4-氨基奎宁为原料,两步法制备了离子液体[ADPQ][BF4],将其用于催化复杂的活性亚甲基化合物与芳香醛的Knoevenagel缩合反应.该反应体系在室温下就可进行,无需任何溶剂,反应时间短,收率高,后处理简单,催化剂重复使用5次后效果变化不大.A 4-amine quinine based ionic liquid was prepared by using a two-step method. The as-prepared ionic liquid was used to catalyze Knoevenagel condensation of aromatic aldehydes with methylene compounds. The effects of the dosage of catalyst,reaction time and temperature were discussed. This method has the advantages of mild conditions,short reaction time,high yield,and simple work-up. In addition,the ionic liquid can be regenerated and recycled 5 times without significant loss of activity.

关 键 词：离子液体 KNOEVENAGEL缩合 亚甲基化合物 

分 类 号：O622.6[理学—有机化学]