大疱性类天疱疮患者血清中抗BP180 IgE、抗BP230 IgE和总IgE间的相关性  

Correlation among total IgE and IgE anti-BP180 or anti-BP230 autoantibodies in patients with bullous pemphigoidi

作　　者：王昱璐 李丽[1] 左亚刚[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院皮肤科,北京100730

出　　处：《基础医学与临床》2016年第8期1046-1050,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(81071301);北京市自然科学基金(7132203)

摘　　要：目的检测大疱性类天疱疮(BP)患者外周血嗜酸粒细胞、血清总IgE、抗BP180和抗BP230的IgE抗体,并分析它们之间的相关性。方法用ELISA方法检测63例BP患者血清的总IgE抗体、抗BP180 IgE抗体和抗BP230IgE抗体水平,并分析患者外周血嗜酸粒细胞水平、BPDAI评分与IgE抗体的相关性。结果 63例BP患者中,总IgE阳性者41例,阳性率65.08%;抗BP180 IgE阳性者37例,阳性率58.73%;抗BP230 IgE抗体阳性者47例,阳性率74.60%。总IgE和抗BP230 IgE呈正相关(r=0.643,P<0.001)。63例患者中共34例记录了外周血嗜酸粒细胞水平,其中19例BP患者外周血嗜酸粒细胞数量增多(55.88%)。BP180 IgE抗体与BPDAI中的红斑评分呈正相关(r=0.934,P<0.05)。结论 IgE在BP致病过程中发挥作用,IgE自身抗体可能主要与BP230相结合,同时抗BP180 IgE可能会引发BP患者红斑。Objective To examine the level of blood eosinophil counts, total IgE and IgE autoantibodies against BP180 and BP230 in sera of bullous pemphigoid （BP） , and to analyze their correlations. Methods Serum ob- tained from 63 BP patients were subjected to measure serum level of total IgE, anti-BP180 IgE and anti-BP230 IgE antibodies by ELISA assays. And analyse the relevance between Blood eosinophils/bullous pemphigoid disease area index（BPDAI） scores and IgE autoantibodies. Results Total IgE, IgE anti-BP180 and IgE anti-BP230 antibodies were positive in 41 （65.08%） ,37 （58.73%） and 47 （74.60%） case of BP patient respectively. Anti-BP230 IgE level showed a strong association with total IgE（ r =0. 643 ,P 〈0. 001 ）. Of 63 patients with BP, 34 were recor- ded blood eosinophil counts. Blood eosinophils increased in 19 patients （55.88%）. Anti-BP180 IgE was signifi- cantly correlated with urticarial/erythema scores （ r = 0. 934, P 〈 0. 05 ）. Conclusions IgE plays a role in the path- ogenesis of BP. IgE autoantibodies may primarily target to BP230. Anti-BP180 IgE may cause urticarial lesions.

关 键 词：大疱性类天疱疮 总IGE 抗BPl180 IGE抗体 抗BP230 IGE抗体 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]