脑脊液持续引流结合鞘内注射治疗术后颅内G^-杆菌感染  

Continuous drainage combined with intrathecal injection on the treatment of Gram-negative bacterial intracranial infections after craniotomy

作　　者：张庭保 欧阳和平 孙登江 任军 汤军 彭彬玉 

机构地区：[1]湖北省第三人民医院神经外科,武汉430033

出　　处：《临床外科杂志》2016年第6期440-441,共2页Journal of Clinical Surgery

摘　　要：目的探讨腰穿置管脑脊液持续引流+鞘内给药在治疗G^-杆菌所致神经外科手术后颅内感染中的作用。方法神经外科术后脑脊液培养结果为G^-杆菌感染的患者34例,均给予腰穿置管脑脊液持续引流,并结合药敏试验结果给予鞘内给药治疗。结果34例患者中32例有效,有效率为94.12%。2例无效,无效率为5.88%,其中1例死亡,死亡率为2.9%,1例自动出院。结论脑脊液持续引流+结合药敏的鞘内注射治疗术后颅内感染,简单、有效。Objective To investigate the role of lumbar puncture and continuous drainage com- bined with intrathecal injection on the treatment of Gram-negative bacterial intracranial infections after craniotomy. Methods The clinical data of 34 neurosurgical cases with positive cerebrospinal fluid culture of Gram-negative bacillus were reviewed from April 2012 to April 2015. All patients received lumbar puncture, continuous drainage, and intrathecal injection according to the result of susceptibility test. Re- sults In the 34 patients ,32 patients were cured and the effective rate was 94.12%. The treatment failed in 2 cases,with an ineffective rate of 5.88%. One of the two patients died（2.9% ） and the other patient was discharged on request. Conclusion For intracranial infections, lumbar puncture and continuous drainage combined with intrathecal injection is simple and effective, which should be widely applied.

关 键 词：脑脊液持续引流 鞘内给药 G-杆菌 颅内感染 

分 类 号：R651.1[医药卫生—外科学]