2型糖尿病发生心房颤动的相关因素分析  

Relevant factors of type 2 diabetes mellitus with atrial fibrillation

作　　者：管枫[1] 张德玲[1] 张叶敏[1] 汪长华[1] 

机构地区：[1]武汉大学基础医学院病理生理学教研室,湖北武汉430071

出　　处：《中国心脏起搏与心电生理杂志》2016年第3期238-241,共4页Chinese Journal of Cardiac Pacing and Electrophysiology

摘　　要：目的分析2型糖尿病合并心房颤动(简称房颤)的相关因素。方法 2014年6月至2015年9月期间,武汉科技大学附属天佑医院收治的2型糖尿病患者192例,其中79例合并房颤(T2DM+AF组),113例为单纯型(T2DM组)。对比分析两组人群的糖尿病相关指标、血生化指标、超声心动图指标以及心电图特征。结果 1与T2DM组比较,T2DM+AF组呈现出更高的空腹血糖、糖化血红蛋白、尿酸、脉压差、高血压患病率发生率;以及更低的左室射血分数(LVEF),伴随有增加的心率、QTc间期、QTc间期延长率、ST-T改变;2两组冠心病、脑卒中、非酒精性肝硬化的发生率并无差异。结论 1糖尿病合并房颤具备更快的心率、更长的QTc间期和更高的ST-T改变发生率;2高血糖、高尿酸、高血压、糖化血红蛋白、低LVEF以及增加的脉压差可能是糖尿病患者并发房颤的危险因素。Objective To analyze relevant factors of type 2 diabetes mellitus （T2DM） with atrial fibrillation （AF）. Methods Between June 2014 and September 2015, 192 patients of T2DM who were referred to the Affiliated Tianyou Hospital of Wuhan University of Science and Technology were analyzed. The subjects investigated were divided into 2 groups： T2DM group（n= 113） and T2DM with AF group（n： 79）. The diabetes-associated biochemistry parameters were measured and echoeardiography,electrocardiogram（ECG） were recorded. Results （1）Compared with T2DM group, T2DM with AF group showed elevated levels of fasting plasma glueose（FPG）, hemoglobin AiC（HbAlc）, uric acid, pulse pressure difference, incidence of hypertension and decreased left ventricular ejection fraction（LVEF） level, accompanied with further increases of heart rate, QTc interval, and ST-T changes. （2） The incidences of coronary heart disease, stroke, and non-alcoholic cirrhosis remain unchanged between T2DM group and T2DM with AF group. Conclusion O T2DM with AF have further increases of heart rate, QTc interval, and ST-T changes. （2） Hyperglycemia,hyperuricemia,hypertension, elevated HbAlc, increased pulse pressure difference and decreased LVEF maybe among the risk factors contribute to AF development. [Chinese Journal of Cardiac Pacing and Electrophysiology, 2016,30 （3） ： 238- 241]

关 键 词：心血管病学 糖尿病 心律失常 心房颤动 危险因素 

分 类 号：R541.75[医药卫生—心血管疾病] R587.1[医药卫生—内科学]