诱导多能干细胞治疗脱发研究新进展  

New Progress in the Study of Induced Pluripotent Stem Cells in the Treatment of Alopecia

作　　者：罗雯[1] 邓丹琪[1] 

机构地区：[1]昆明医科大学第二附属医院皮肤性病科

出　　处：《医学综述》2016年第14期2745-2747,共3页Medical Recapitulate

摘　　要：脱发性疾病是临床上常见的一组影响美容、心理和健康的疾病。目前,脱发性疾病的发病机制仍不甚清楚。毛囊结构、毛乳头细胞及毛囊干细胞异常可能与脱发性疾病密切相关。诱导多能干细胞(i PSC)是将外源性转录因子导入已分化的体细胞中并重新编排形成的具有类似于胚胎干细胞全能性的多潜能细胞,在临床医学和再生医学方面具有广阔的应用前景。i PSC可分化为毛乳头细胞、毛囊干细胞及再生毛囊,为治疗脱发性疾病开辟了新道路。Alopecia, as s common disease, can affect people＇s beauty, psychology and health. At present, the pathogenesis of alopecia remains poorly understood. The research shows that hair follicle structure, hair papilla ceils and hair follicle stem cells abnormalities are closely related to alopecia. Induced pluripotent stem cells （iPSC） are multipotential cells with the potential to be rearranged in differentiated somatic cells, similar to embryonic stem cells,which holds great hope for the clinical medicine and regenerative medicine, iPSC can be differentiated into dermal papilla cells, hair follicle stem cells and regenerated hair follicles, opening up a new way for the treatment of alopecia.

关 键 词：脱发 诱导多能干细胞 毛乳头细胞 毛囊干细胞 

分 类 号：R758.7[医药卫生—皮肤病学与性病学]