低分子肝素联合氨溴索对婴幼儿肺炎患儿潮气呼吸肺功能指标的影响  

Effect of Low Molecular Weight Heparin Combined with Ambroxol on Tidal Breathing Lung Function of Infants with Pneumonia

作　　者：王洪洲[1] 祝介云[1] 

机构地区：[1]临朐县人民医院儿科,山东临朐262600

出　　处：《医学综述》2016年第14期2877-2880,共4页Medical Recapitulate

摘　　要：目的探讨低分子肝素联合氨溴索对婴幼儿肺炎患儿潮气呼吸肺功能指标的影响。方法选取自2013年1月至2014年1月临朐县人民医院收治的婴幼儿重症肺炎100例,按随机数字表法将其分为对照组和观察组,各50例。两组患儿均采取常规治疗,对照组在此基础上采用30 mg氨溴索加入5 m L 0.9%Na Cl注射液中混匀后雾化吸入;观察组患儿在雾化吸入氨溴索的同时静脉注射剂量为1 mg/(kg·d)的低分子肝素。另选取同期来本院进行体检的健康婴幼儿作为空白对照组。采用Master Screen Paed肺功能仪检测两组患儿治疗前后的各项潮气呼吸肺功能指标,并与健康婴幼儿比较。比较两组患儿治疗后疗效及临床症状、体征的消失时间。结果观察组患儿治疗后的总有效率显著高于对照组,差异有统计学意义[92.0%(46/50)比70.0%(35/50),P<0.05]。观察组患儿治疗后气促、咳嗽、发绀、三凹征、肺部湿啰音等症状及体征的消失时间均显著短于对照组[(3.18±1.27)d比(6.4±1.6)d、(1.38±0.91)d比(3.7±1.2)d、(2.04±0.86)d比(3.9±1.5)d、(2.42±0.67)d比(4.0±1.1)d、(3.46±0.84)d比(6.8±1.7)d](P<0.05)。治疗后,对照组患儿的呼吸频率(RR)、潮气量(TV)、吸气时间(tI)、呼气峰值流速(PEF)、呼气时间(tE)、达峰时间比(tPEF/tE)、达峰容积比(VPEF/VE)、呼气中期流速/吸气中期流速(ME/MI)分别为(39±4)次/min、(6.9±1.4)m L、(0.65±0.16)s、(1.13±0.22)s、(22±5)、(21±5)、(101±43)m L/s、(0.69±0.23),观察组RR、TV、tI、tE、tPEF/tE、VPEF/VE、PEF、ME/MI分别为(38±5)次/min、(7.0±1.2)m L、(0.67±0.13)s、(1.16±0.29)s、(25±6)、(24±4)、(100±47)m L/s、(0.70±0.18),两组患儿各项指标(ME/MI除外)与治疗前相比均有明显改善,差异有统计学意义(P<0.05);且两组患儿治疗各项治疗(ME/MI除外)均明显改善并与空白对照组比较差异有统计学意义(P<0.05),但两组间疗效指标(TPEF/TE、VPEF/VE除外)比较差异无统计�Objective To investigate the effect of low molecular weight heparin combined with ambrexol on tidal breathing lung function in infant patients with pneumonia. Methods Total of 100 infants with severe pneumonia admitted to Linqu County People＇s Hospital from Jan. 2013 to Jan. 2014 were included in the study, according to a random number table they were divided into a control group and the observation group, 50 cases each. Both groups were given conventional treatment, on the basis of which the control group was added with 30 mg ambrexol added into 5 mL 0. 9% NaC1 injection for inhalation;the observation group was further added with intravenous injection of 1 mg/（ kg ·d） of low molecular weight heparin. And healthy infants for medical examination during the same period were included as controls. Master Screen Paed was used to detect the tidal breathJing lung function of the two groups before and after treatment with healthy infants as comparison. Efficacy and clinical symptoms/signs disappearing time of the two groups after treat- ment were compared. Results The total effective rate of the observation group than the control group, thedifference was statistically significant [92. 0% （46/50） vs 70. 0% （35/50）, P 〈 O. 05 ]. After treatment the shortness of breath, coughing, cyanosis, three concave syndrome, pulmonary rale, and other symptoms and signs disappearing time of the observation group were significantly shorter than the control group[ （3. 18：1： 1.27） dvs （6.4±1.6）d,（1 38 ±0.91） d vs （3.7 ±1.2） d,（2.04±0.86） d vs （3.9 ±1.5） d, （2. 42 ± O. 67 ） d vs （4. 0 ± 1.1 ） d, （ 3.46 ± 0. 84） d vs （6. 8 ± 1.7） d ] （ P 〈 0. 05 ）. After treatment the repetition rate（ RR）, tidal volume（TV） , inspiratory time（ t1 ） , peak expiratory flow rate （PEF） , expiratory time （tE ） , tpEF/tE, VpEF/VE, mid-expiratory flow rate/intake flow rate medium-term （ME/MI） of the control group were （39 ±4） times/min,（6.9±l.4） mL,（0.65±

关 键 词：肺炎 低分子肝素 氨溴索 肺功能 

分 类 号：R453.9[医药卫生—治疗学]