异维A酸胶囊对中度寻常痤疮严重程度及患者生活质量的影响  

Clinical Efficiency and Life Quality Effect of Isotretinoin Capsule in Treatment with Moderate Acne Vulgaris

作　　者：沈跃莉[1] 叶俊儒[1] 

机构地区：[1]成都医学院第一附属医院皮肤性病科,成都610500

出　　处：《医学综述》2016年第14期2888-2891,共4页Medical Recapitulate

摘　　要：目的探讨异维A酸胶囊对中度寻常痤疮严重程度及患者生活质量的影响。方法将2013年6月至2015年6月在成都医学院第一附属医院就诊的120例寻常痤疮患者按照随机数字表法分为观察组和对照组,各60例。观察组口服异维A酸胶囊治疗,每次10 mg,每日2次;对照组口服维胺酯胶囊治疗,每次50 mg,每日2次。两组患者均治疗6周。比较两组患者治疗前和治疗后2、4、6周皮损数量及皮损积分,采用痤疮特异性生活质量调查表评价两组患者治疗前后生活质量,并记录两组患者不良反应发生率及临床疗效。结果治疗后2、4、6周,观察组皮损数量少于对照组[(28±5)枚比(32±6)枚,(21±4)枚比(27±5)枚,(15±2)枚比(18±3)枚],皮损积分低于对照组[(11.7±3.2)分比(13.5±2.9)分,(9.4±2.6)分比(11.4±3.0)分,(7.4±1.5)分比(9.8±1.8)分],差异有统计学意义(P<0.05)。治疗后,观察组情感功能、社会功能、自我感知评分显著高于对照组[(9.4±2.1)分比(6.9±1.7)分,(14.3±2.9)分比(11.9±2.5)分,(10.1±1.3)分比(8.6±1.1)分],差异有统计学意义(P<0.05)。观察组皮肤干燥、皮肤瘙痒发生率低于对照组[3.3%(2/60)比13.3%(8/60),8.3%(5/60)比28.3(17/60)],差异有统计学意义(P<0.05)。治疗后,观察组总有效率显著高于对照组[91.7%(55/60)比81.7%(49/60)],差异有统计学意义(P<0.05)。结论异维A酸胶囊治疗中度寻常痤疮疗效较好,安全性更高,且患者生活质量得到显著提升,值得临床推广。Objective To explore the clinical efficiency and life quality effect of isotretinoin capsule in treatment with moderate acne vulgaris. Methods A total of 120 moderate acne vulgaris patients treated in outpatient service from June 2013 to June 2015 accorded to the random number table method were randomly divided into observation group 60 cases and control group of 60 cases, observation group was treated with oral isotretinoin capsules, 10 mg each time,2 times daily, while the control group oral viaminate capsule,50 rag/ times,2 times daily,two groups of patients were treated 6 weeks for a course. The clinical efficacy of the two groups were compared, and the number of lesions,skin lesion score were recorded before and after 2 week,4 week ,6 week treatment, the life quality of the two groups were evaluated by quality of life-Acne, and the inci- dence of adverse reactions in the two groups were recorded. Results After treatment 2,4,6 week, the lesions number of observation group were less than the control group [ （28 ± 5 ） vs （ 32 ±6 ） , （21 ± 4） vs （27 ± 5 ） , （ 15 ±2） vs （ 18 ± 3 ） ] ,the skin lesion score were lower than the control group[ （ 11.7 ± 3.2） scores vs （ 13.5 ± 2.9） scores, （9.4 ± 2.6） scores vs （ 11.4 ± 3.0） scores, （7.4 ± 1.5 ） scores vs （9.8 ± 1.8 ） scores ], the difference between the two groups was statistically significant（ P 〈 0.05 ）. After treatment, emo- tional function, social function, self perception of observation group were significantly higher than the control group[ （9.4 ±2.1 ） scores vs （6.9 ± 1.7） scores, （ 14.3 ±2.9） scores vs （ 11.9 ±2.5 ） scores, （ 10.1 ± 1.3 ） scores vs （8.6 ± 1.1 ） scores ] ,the difference between the two groups was statistically significant（ P 〈 0.05）. The incidence of skin dryness and pruritus in the observation group was significantly lower than that in the control group [ 3.3 % （2/60） vs 13.3 % （ 8/60 ）, 8.3% （ 5/60 ） vs 28.3 % （ 17/60 ）, P �

关 键 词：寻常痤疮 异维A酸 生活质量 皮损积分 

分 类 号：R753.3[医药卫生—皮肤病学与性病学]